ID A0A3P8QFD2_ASTCA Unreviewed; 466 AA.
AC A0A3P8QFD2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Tubby-like protein {ECO:0000256|RuleBase:RU361125};
GN Name=TULP3 {ECO:0000313|Ensembl:ENSACLP00000027971.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000027971.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000027971.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000027971.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TUB family. {ECO:0000256|ARBA:ARBA00007129,
CC ECO:0000256|RuleBase:RU361125}.
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DR AlphaFoldDB; A0A3P8QFD2; -.
DR Ensembl; ENSACLT00000028626.1; ENSACLP00000027971.1; ENSACLG00000018961.1.
DR GeneTree; ENSGT00940000158155; -.
DR Proteomes; UP000265100; Chromosome 17.
DR Bgee; ENSACLG00000018961; Expressed in brain and 6 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR025659; Tubby-like_C.
DR InterPro; IPR000007; Tubby_C.
DR InterPro; IPR018066; Tubby_C_CS.
DR InterPro; IPR005398; Tubby_N.
DR PANTHER; PTHR16517:SF167; TUBBY-LIKE PROTEIN; 1.
DR PANTHER; PTHR16517; TUBBY-RELATED; 1.
DR Pfam; PF01167; Tub; 1.
DR Pfam; PF16322; Tub_N; 2.
DR PRINTS; PR01573; SUPERTUBBY.
DR PRINTS; PR01574; TUBBYPROTEIN.
DR SUPFAM; SSF54518; Tubby C-terminal domain-like; 1.
DR PROSITE; PS01200; TUB_1; 1.
DR PROSITE; PS01201; TUB_2; 1.
PE 3: Inferred from homology;
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 20..75
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 75..199
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 216..461
FT /note="Tubby C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01167"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 466 AA; 52652 MW; 667D6437DF3E9A43 CRC64;
MFQHGVENDS SSLMQQKLEK QRALLEQKQR QKRQQHLMVQ PNTEVRPRRS RARRGEEQAP
LVESQLNVTN DVIIDGIDGP AAFLSSEPPD IGMKIQILSV SQSQSQSQPE SQSQSQSPAA
EEPERDGDTE TLLEPKTDIH ELLQKQGLCE SMNFDEASEH EEDLEEERTR SRSSHTDSNR
PASATSGKDI PDLVTPGSPT AENLLADVAN LEEFVLRPAP RGVTVKCRIT RDKKGMDRGL
YPTYYMHMEK EDCKKVFLLA GRKRKKSKTS NYLISVDATD LSREGESFIG KLRSNLMGTK
FTVYDNGTNP CKNPGALLEE SNTRQELAAI CYETNVLGFK GPRKMTVIIP GMNMNFERLP
VRPQNEQESL LSRWQNHSLE NLIELHNKAP VWNDDTQSYV LNFHGRVTQA SVKNFQIVHD
NDPDYIVMQF GRVAEDVFTL DYNYPMCALQ AFAIGLSSFD SKLACE
//
