ID A0A3P8QFG5_ASTCA Unreviewed; 853 AA.
AC A0A3P8QFG5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Discs, large homolog 3 (Drosophila) {ECO:0000313|Ensembl:ENSACLP00000028295.1};
GN Name=DLG3 {ECO:0000313|Ensembl:ENSACLP00000028295.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000028295.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000028295.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000028295.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8QFG5; -.
DR Ensembl; ENSACLT00000028957.1; ENSACLP00000028295.1; ENSACLG00000019062.1.
DR GeneTree; ENSGT00940000159565; -.
DR Proteomes; UP000265100; Chromosome 2.
DR Bgee; ENSACLG00000019062; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12029; SH3_DLG3; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR InterPro; IPR016313; DLG1-like.
DR InterPro; IPR035763; DLG3_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF28; DISKS LARGE HOMOLOG 3; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF10600; PDZ_assoc; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 134..221
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 229..316
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 390..471
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 505..575
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 663..838
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 41..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 853 AA; 94040 MW; 3D6A5DE16654B07C CRC64;
MHKHHHCCKC PECYEVTRMA ALRRMDAPSY GGDWQAEPYG YPPGYGGGQT LPPPASGGGG
SMGGGGGTLG RSKGKVMSGG GPGGPNPKGQ SKGGPKVNGN NSSGQGGWWP ECTCTNREWY
DQVNGSDGMY KYEEIILERG NSGLGFSIAG GIDNPHIPDD PGIFITKIIP GGAAAMDGRL
GVNDCVLRVN DVDVSEVVHS RAVEALKEAG PVVRLLVRRR QAPPETILEV NLLKGPKGLG
FSIAGGIGNQ HIPGDNSIYI TKIIEGGAAQ KDGRLQTGDR LLAVNNIVLQ DVRHEEAVAA
LKNTSDMVYL KVAKPGPVHL NDMYAPPDYS SSLALPPAFP TMVDNHVSHN YMGGMEPKPV
YPPPQVTPSR YSPVPRHMMG EEDFTREPRK VVLHKGSTGL GFNIVGGEDG EGIFVSFILA
GGPADLSGEL RRGDRILSVN GVNLRNATHE QAAAALKRAG QTVTIIAQYR PEEYSRFESK
IHDLREQMMN SSMSSGSGSL RTSEKRSLYV RALFDYDRTR DSCLPSQGLS FSYGDILHVI
NASDDEWWQA RLVTPHGESE QIGVIPSKKR VEKKERARLK TVKFHARTGM IESNRPVKVK
RKKSFNLSRK FPFYKSKENI VQELVESEQC LTSNTSDSES SSKGQEDTIL SYEPVIRQEI
HYTRPVIILG PMKDRINDDL ISEFPHKFGS CVPHTTRPRR ENEIDGQDYH FVGSREQMEK
DIQDNKFIEA GQFNENLYGT SILSVRTVAE RGKHCILDVS GNAIKRLQQA QLYPIAIFIK
PKSIEALMEM NKRQTYEQAN KVFDKAVKLE QDFGEYFTAI VQGDSLEEIY NKIKLIIEEQ
SGPYIWIPSS EKL
//
