ID A0A3P8QG06_ASTCA Unreviewed; 889 AA.
AC A0A3P8QG06;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Rho GTPase activating protein 9 {ECO:0000313|Ensembl:ENSACLP00000027929.1};
GN Name=ARHGAP9 {ECO:0000313|Ensembl:ENSACLP00000027929.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000027929.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000027929.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000027929.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8QG06; -.
DR STRING; 8154.ENSACLP00000027929; -.
DR Ensembl; ENSACLT00000028582.1; ENSACLP00000027929.1; ENSACLG00000018988.1.
DR GeneTree; ENSGT00950000182860; -.
DR OMA; ELRAWHH; -.
DR Proteomes; UP000265100; Chromosome 5.
DR Bgee; ENSACLG00000018988; Expressed in spleen and 5 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13233; PH_ARHGAP9-like; 1.
DR CDD; cd04403; RhoGAP_ARHGAP27_15_12_9; 1.
DR CDD; cd12143; SH3_ARHGAP9; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035465; ARHGAP9_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23176:SF103; RHO GTPASE-ACTIVATING PROTEIN 9; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00397; WW; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 33..99
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 311..339
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 481..593
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 676..883
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 191..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 889 AA; 99828 MW; 720FB43DBC388C69 CRC64;
MLSGSWRRSF GHQQPAAGSV VNSRGMTVCG VPSGTVVLEA QYDYSYRGAD GRQVCIREGE
RFILLKKTNA DWWQVRRIGA ASKAKPLYVP ATYVTEVPIA PMPSPQRLTA TASLNTNFRI
LPRVSLSPSA TGATNNEQRQ VNKLLYHSME NLNSNSVFQG LKNNTSVDRG HFPTLPLSGF
TFASNSPTSS SGHLMVPGSQ ATSTAETAPT NSRVVPTITR SQSSNNLPEN LMENPYDEVG
GGFSSRTNHR IPKKSCSQWD VAGASGKNNH LQLSWQDSPL YTEKQTEKRQ SQPEPPSPAP
GEQPLQILGL WEQYCDATTG RWYYVNSITK ERSWKPPRRA RGQYTNQAGP GQPQTLPRDT
SHLSLSLTAA GNGTTHRLSP DFLFGSHQRN ADNGWQMKQS MQRAASSDTL STMAFSDTRT
QCDDSAPLHD VKQQLNHSQS MILPDNKLVQ QCRDYSRNVT NIVVEPPSPA SSPDSDGCTP
ELEKAGLLNK TKIAEGGRKL RKNWSPSWVV LVGNSLVFFK DPKSQTPSSW KPGNSRPESS
VDLRGAKLHW ANELSSKKNV FKLRTVTGNE FLLQSETDSL IREWYSTIQN VIDRLDRENP
LDNVLLYSLR RAGSVEMLDQ SGDEDDRRPS LPRSTSNLEN TERKRVKTRL KKLILKRPPL
QALQEKGLIK DQVFGCSLEM LCERERSTVP RFVRLCTEAV ERRGLETDGI YRVSGNLAVI
QKLRFLVNHE RAVTTDGRYM FPAELVQEEK LNLDESEWED IHVITGALKL FFRELPEPLV
PYGFFTDIVE TVKMSDYMDK IDRLKCLVLN MPPPNHDTLQ FMCRHLKRVL EQSETNRMTT
QNIGIVFGPT LMRPERDNGN MAVNMVYQNQ AVELILTEFD HIFGTRGLS
//
