ID A0A3P8QJ94_ASTCA Unreviewed; 313 AA.
AC A0A3P8QJ94;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Interferon regulatory factor {ECO:0000256|PIRNR:PIRNR038196};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000029271.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000029271.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000029271.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038196}.
CC -!- SIMILARITY: Belongs to the IRF family. {ECO:0000256|PIRNR:PIRNR038196}.
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DR AlphaFoldDB; A0A3P8QJ94; -.
DR Ensembl; ENSACLT00000029958.1; ENSACLP00000029271.1; ENSACLG00000019528.1.
DR GeneTree; ENSGT00940000159063; -.
DR Proteomes; UP000265100; Chromosome 2.
DR Bgee; ENSACLG00000019528; Expressed in zone of skin and 8 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:InterPro.
DR CDD; cd00103; IRF; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR InterPro; IPR017431; IRF1/IRF2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR PANTHER; PTHR11949:SF22; INTERFERON REGULATORY FACTOR 2; 1.
DR Pfam; PF00605; IRF; 1.
DR PIRSF; PIRSF038196; IFN_RF1/2; 1.
DR PRINTS; PR00267; INTFRNREGFCT.
DR SMART; SM00348; IRF; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51507; IRF_2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|PIRNR:PIRNR038196};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR038196};
KW Nucleus {ECO:0000256|PIRNR:PIRNR038196};
KW Transcription {ECO:0000256|PIRNR:PIRNR038196};
KW Transcription regulation {ECO:0000256|PIRNR:PIRNR038196}.
FT DOMAIN 5..113
FT /note="IRF tryptophan pentad repeat"
FT /evidence="ECO:0000259|PROSITE:PS51507"
FT REGION 115..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 313 AA; 35707 MW; AA4D6DC6811DCB59 CRC64;
MPVERMRMRP WLQEQIESCQ IPGLKWLNKE KRIFQIPWMH AARHGWDLEK DAPLFMRWAI
HTGKYQPGVD RPDPKTWKAN FRCAMNSLPD IEEVKDKSIK KGTNAFRVYK MLSSSERNAK
KGKKKADKER KSKGNKEVDK RDIGVLYSHI RSLQIQRIMN PLILTLLCPS SVIHSQAEDH
VITSEQLPFV CQTIEVTTEN EEQTVSSSHP YPLDTESDTE NIKEGIGAAW RRDYSTSVLR
IPPCSLPGMA TFVSTTKPNF KVTSTQDPSP LISYHTDGWT PTYNQNSLVS TPGTHTHEVR
ASVIMKTSDI TSS
//
