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Database: UniProt
Entry: A0A3P8QKN1_ASTCA
LinkDB: A0A3P8QKN1_ASTCA
Original site: A0A3P8QKN1_ASTCA 
ID   A0A3P8QKN1_ASTCA        Unreviewed;       681 AA.
AC   A0A3P8QKN1;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=procollagen-proline 3-dioxygenase {ECO:0000256|ARBA:ARBA00012262};
DE            EC=1.14.11.7 {ECO:0000256|ARBA:ARBA00012262};
GN   Name=P3H2 {ECO:0000313|Ensembl:ENSACLP00000029622.1};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000029622.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000029622.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000029622.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC         Evidence={ECO:0000256|ARBA:ARBA00001962};
CC   -!- COFACTOR:
CC       Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC         Evidence={ECO:0000256|ARBA:ARBA00001961};
CC   -!- SIMILARITY: Belongs to the leprecan family.
CC       {ECO:0000256|ARBA:ARBA00006487}.
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DR   AlphaFoldDB; A0A3P8QKN1; -.
DR   STRING; 8154.ENSACLP00000029622; -.
DR   Ensembl; ENSACLT00000030321.1; ENSACLP00000029622.1; ENSACLG00000020074.1.
DR   GeneTree; ENSGT00940000159593; -.
DR   OMA; LECARSY; -.
DR   OrthoDB; 5398065at2759; -.
DR   Proteomes; UP000265100; Chromosome 23.
DR   Bgee; ENSACLG00000020074; Expressed in spleen and 7 other cell types or tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR   GO; GO:0019797; F:procollagen-proline 3-dioxygenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032963; P:collagen metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR   InterPro; IPR039575; P3H.
DR   InterPro; IPR006620; Pro_4_hyd_alph.
DR   InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR14049; LEPRECAN 1; 1.
DR   PANTHER; PTHR14049:SF1; PROLYL 3-HYDROXYLASE 2; 1.
DR   Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR   SMART; SM00702; P4Hc; 1.
DR   PROSITE; PS51471; FE2OG_OXY; 1.
PE   3: Inferred from homology;
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..681
FT                   /note="procollagen-proline 3-dioxygenase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018035475"
FT   DOMAIN          530..644
FT                   /note="Fe2OG dioxygenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51471"
SQ   SEQUENCE   681 AA;  77772 MW;  AD9C54A62849E63C CRC64;
     MDGNLFPTLI FLPVLLSAVL PSSAGVLEPY DLLYDNAVEA FYSADYESVV RYMEGALSSH
     RQVRATRVRC RLRCQDQHPL DESFSDLRFF DSVLRRAACM NKCIEEKVGT QSLHKVSEDV
     VQDFNRRIPY NYLQQAYQKL QRPDKAAEAA HTYFQANPEH VEMGRDLEQY KNLQGVEETH
     FVDREARPHQ RSFTAAVQLY DKGDYEGATA LFEEALVEYY KADVDCRALC QGPQKFEGQD
     HLRYRYSLHE VVSDHFTQVL HCEHECVRDL ATRPGRLSPM ENYLPLHYDY LQFAYFKAGR
     LEEALQCALT YLLFHEGEEF MKENADYYRE ELGHDAEPRE KAAWYLRRHK QELKLLLIGS
     KIMGAEFTEG NYWRSTGGRD DSNSVPSGTD GWMEYVPISH KKNVTVTSPQ SLKEGGPLLY
     EGVQLVQNSA ALNGTQRVLL DHVLSEEECA ELRQLAHTVT MAGDGYKGRM SPHTPNEKFE
     GASVLKTLQH GFEGRVPMRS ARLFYETSER ARRIIESYFV LNSTLHFSYT HLVCRTAIKG
     QQDHRNDLSH PIHADNCLLD PDANECWKEP PAYTNRDYSA LLYLNADFEG GEFVFTEMDA
     KTVTASVKPK CGRMVGFSSG GENPHGVKAV TSGQRCAVAL WFTLNPLYRE LERLQADEVV
     QALDTQHVFG QGLNINPKDE L
//
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