ID   A0A3P8QMA4_ASTCA        Unreviewed;       442 AA.
AC   A0A3P8QMA4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Cystatin domain-containing protein {ECO:0000259|SMART:SM00043};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000030104.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000030104.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000030104.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8QMA4; -.
DR   STRING; 8154.ENSACLP00000030104; -.
DR   Ensembl; ENSACLT00000030813.1; ENSACLP00000030104.1; ENSACLG00000020399.1.
DR   GeneTree; ENSGT00950000182930; -.
DR   OMA; ARHAFCR; -.
DR   Proteomes; UP000265100; Chromosome 17.
DR   Bgee; ENSACLG00000020399; Expressed in liver and 2 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd00042; CY; 1.
DR   Gene3D; 3.10.450.10; -; 2.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   PANTHER; PTHR13814:SF16; CYSTATIN; 1.
DR   PANTHER; PTHR13814; FETUIN; 1.
DR   Pfam; PF00031; Cystatin; 2.
DR   SMART; SM00043; CY; 2.
DR   SUPFAM; SSF54403; Cystatin/monellin; 2.
PE   4: Predicted;
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..442
FT                   /note="Cystatin domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018152005"
FT   DOMAIN          60..170
FT                   /note="Cystatin"
FT                   /evidence="ECO:0000259|SMART:SM00043"
FT   DOMAIN          183..290
FT                   /note="Cystatin"
FT                   /evidence="ECO:0000259|SMART:SM00043"
FT   REGION          298..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..398
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   442 AA;  48200 MW;  433DE8F435625200 CRC64;
     MFVLWSLLFI YHLFPNPLTY VNQSTLYNSP VIVACSSLLC GTMRTLRVLT LLSAAVLLCS
     AAPGLEPLTC SEGNGPAAAE KAVHHINEHH DHGYKFRLHE VQGNSVEQVD GGCNVKLQLD
     LRETKCHTIN PKPFEDCEIR GMGERAVKAN CTVLMTIKDG DADITKYECD TRQEKTNLEM
     VRICPDCPVL LPLNNSEGLK SVREATAEFN KNTSNQHYYI LKEVGRISSG YIMGLGMNYY
     PEFALVETHC PMGSRIVIEA CIPLCPNRAR HAFCRSSYSS QNGLLSTECD FYPAENTTAL
     GPGEKEPVCG RHPHGHGGPP PHAHDHGRGP PPHAHDHGHG PPPDAGKGGR PPHAHDHGRG
     PPPDAAKEGR PPHAHGPPPH ADKGGRPPHA HDHGHGPPPT GGKGKGSFHP LRRFHPCHGF
     LVNPDPALHP ICPWPLPHRP HN
//