ID   A0A3P8QN32_ASTCA        Unreviewed;       897 AA.
AC   A0A3P8QN32;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Eukaryotic translation initiation factor 4 gamma 2 {ECO:0000256|ARBA:ARBA00040449};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000031035.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000031035.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000031035.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Appears to play a role in the switch from cap-dependent to
CC       IRES-mediated translation during mitosis, apoptosis and viral
CC       infection. Cleaved by some caspases and viral proteases.
CC       {ECO:0000256|ARBA:ARBA00037759}.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC       {ECO:0000256|ARBA:ARBA00005775}.
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DR   AlphaFoldDB; A0A3P8QN32; -.
DR   STRING; 8154.ENSACLP00000031035; -.
DR   Ensembl; ENSACLT00000031761.1; ENSACLP00000031035.1; ENSACLG00000021001.1.
DR   GeneTree; ENSGT00940000154675; -.
DR   OMA; CAPLDIN; -.
DR   Proteomes; UP000265100; Chromosome 7.
DR   Bgee; ENSACLG00000021001; Expressed in ovary and 8 other cell types or tissues.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   CDD; cd11559; W2_eIF4G1_like; 1.
DR   Gene3D; 1.25.40.180; -; 3.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045208; IF4G.
DR   InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   InterPro; IPR003307; W2_domain.
DR   PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR   PANTHER; PTHR23253:SF82; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2; 1.
DR   Pfam; PF02847; MA3; 1.
DR   Pfam; PF02854; MIF4G; 1.
DR   Pfam; PF02020; W2; 1.
DR   SMART; SM00515; eIF5C; 1.
DR   SMART; SM00544; MA3; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; ARM repeat; 3.
DR   PROSITE; PS51366; MI; 1.
DR   PROSITE; PS51363; W2; 1.
PE   3: Inferred from homology;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          534..657
FT                   /note="MI"
FT                   /evidence="ECO:0000259|PROSITE:PS51366"
FT   DOMAIN          711..894
FT                   /note="W2"
FT                   /evidence="ECO:0000259|PROSITE:PS51363"
FT   REGION          481..531
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        483..512
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   897 AA;  102670 MW;  93CCCCF9070EB4FB CRC64;
     MLEQLRISLY PPQIEILCQY TQSLALYFYS EFLGKTPGQS VQRWVPSRST RRDVNSSNEK
     ERHDAIFRKV RGILNKLTPE KFDKLCLELL NVGVDSKLVL KGIILLIVDK ALEEPKYSSL
     YAQLCLRLAE DAPNFDGTSP DIQTPQKQST TFRRLLISKL QDEFENRTRN VEIYDKHDNP
     LTSEEEEQRA IAKIKMLGNI KFIGELGKLD LIHESILHKC IKTLLEKKKR VQLKDMGEDL
     ECLCQIMRTV GPRLDHEKAK SLMDQYFGRM RSLMNNKELP ARIRFLLQDT VELRENNWVP
     RKAFIDNGPK TINQIRQDAV KDLGVFIPAP MSQGMRMDFF LESPFMPSRM KLDRETLGGL
     ADMFGQMPGS GIGTGPGVIQ DRYSPTMGRH RTNPLFNGHG GHIAPPPQSQ FDMGPKSFVK
     SNQVQNQHFL NQNQNHMAQQ QVQSKDMPPR FSKKGQLNAD EISLRPAQSF LLNKNQVPKL
     QPQIPTMMPP SAQPPRTQTP PLGQPPQLGL KTNPPPIQEK PQKTNKKPPP AKEELLKMTE
     AIMTEYLNTK NLTEAVSGVR EMKAPKHFLP EMLSKIIVCS LDCPDEDKEH ASTLIHTLRT
     EGLITGENFM QAFLNVLDQC PKIEVDVPLV KSYLAQFAAR AIIAELVSVA ELAHPLENGT
     HFPLFLLCLQ QTAKLKDREW LTDLFQQSKV NMQKMLPEID QNKDRMLEIL EGKGLSFLFP
     LLKLEKELLK QIKADPSPQS IYKWIKDNIS PKFHTDKGFV NILMTSFLQY ISQELCEAEG
     DEQLAAPSKE MLEQEKQLLL AFKPVMQKFL HDHTELQVSA LYALQVHCNA RGFPKGMLLR
     YFVNFYDMEI IEEEAFLAWK EDITQEFPGK GKALFQVNQW LTWLETAEEE ESEDDAD
//