ID A0A3P8QNC9_ASTCA Unreviewed; 387 AA.
AC A0A3P8QNC9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Pseudouridylate synthase RPUSD4, mitochondrial {ECO:0000256|ARBA:ARBA00039953};
DE AltName: Full=RNA pseudouridylate synthase domain-containing protein 4 {ECO:0000256|ARBA:ARBA00041563};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000030978.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000030978.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000030978.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in mRNA = a pseudouridine in mRNA;
CC Xref=Rhea:RHEA:56644, Rhea:RHEA-COMP:14658, Rhea:RHEA-COMP:14659,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|ARBA:ARBA00001166};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in tRNA = a pseudouridine in tRNA;
CC Xref=Rhea:RHEA:54572, Rhea:RHEA-COMP:13339, Rhea:RHEA-COMP:13934,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|ARBA:ARBA00036943};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=uridine in 5S rRNA = pseudouridine in 5S rRNA;
CC Xref=Rhea:RHEA:47036, Rhea:RHEA-COMP:11730, Rhea:RHEA-COMP:11731,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|ARBA:ARBA00001896};
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DR AlphaFoldDB; A0A3P8QNC9; -.
DR SMR; A0A3P8QNC9; -.
DR STRING; 8154.ENSACLP00000030978; -.
DR Ensembl; ENSACLT00000031703.1; ENSACLP00000030978.1; ENSACLG00000020996.1.
DR GeneTree; ENSGT00940000158436; -.
DR OMA; AKKYWAI; -.
DR OrthoDB; 2901925at2759; -.
DR Proteomes; UP000265100; Chromosome 5.
DR Bgee; ENSACLG00000020996; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF93; PSEUDOURIDYLATE SYNTHASE RPUSD4, MITOCHONDRIAL; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE 4: Predicted;
FT DOMAIN 124..299
FT /note="Pseudouridine synthase RsuA/RluA-like"
FT /evidence="ECO:0000259|Pfam:PF00849"
FT REGION 32..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 387 AA; 43103 MW; 5C3EDE6B3E34A4CA CRC64;
MNSCGRLARV FDRSSGLDVL FCLAKPRTTC RQCPQTTPPL ARGQSTAANH TPGSDADDKP
RVRAVDLARK IRGEKSKTRE TAPPMSAQQR RVMELKRFSV QLQNVHPNVL AKHLHRSVLY
QDKDVVIVNK PYGIPVADDS DVTSITSVLP VLSKMMDGMK IKSDSQLIPC LGLEKDSTGT
LLLARRDEVV EHVLALNRNN KVERKYWVIT VGVPVPSEGL IDIPIIEREV TGPQPHYKMA
LSPLYRLNDE GDGVTKVRSH RQAHPALTKY RVLDSSSGCS LVELQPFTGV KHQMRVHMAF
ALGCPILGDH KYSHWSKLAP QKLPERVLGK LGIEQSKVRH LPLHLHARQL TLPGSSQADV
NVSCPLPKYF TQTLGRLHIT LPDEKQT
//