ID   A0A3P8QPH2_ASTCA        Unreviewed;       580 AA.
AC   A0A3P8QPH2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Inhibitor of apoptosis protein-like {ECO:0000313|Ensembl:ENSACLP00000031555.1};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000031555.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000031555.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000031555.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the IAP family. {ECO:0000256|ARBA:ARBA00006672}.
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DR   AlphaFoldDB; A0A3P8QPH2; -.
DR   Ensembl; ENSACLT00000032297.1; ENSACLP00000031555.1; ENSACLG00000021356.1.
DR   GeneTree; ENSGT00940000154175; -.
DR   Proteomes; UP000265100; Chromosome 10.
DR   Bgee; ENSACLG00000021356; Expressed in anal fin and 8 other cell types or tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd00022; BIR; 2.
DR   CDD; cd16713; RING-HC_BIRC2_3_7; 1.
DR   CDD; cd14394; UBA_BIRC2_3; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001370; BIR_rpt.
DR   InterPro; IPR048875; BIRC2-3-like_UBA.
DR   InterPro; IPR041933; BIRC2/BIRC3_UBA.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR10044:SF79; BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR10044; INHIBITOR OF APOPTOSIS; 1.
DR   Pfam; PF00653; BIR; 2.
DR   Pfam; PF21290; BIRC2-3-like_UBA; 1.
DR   Pfam; PF00619; CARD; 1.
DR   Pfam; PF13920; zf-C3HC4_3; 1.
DR   SMART; SM00238; BIR; 2.
DR   SMART; SM00114; CARD; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF57924; Inhibitor of apoptosis (IAP) repeat; 2.
DR   PROSITE; PS01282; BIR_REPEAT_1; 1.
DR   PROSITE; PS50143; BIR_REPEAT_2; 2.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          415..505
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
FT   DOMAIN          533..568
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          95..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..114
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   580 AA;  64572 MW;  F23965D8949B8263 CRC64;
     MGLHLNCNMI TPQSSSASQP LLDSQHLRSP NEVWREQSLP STANLLSSSH SAFSPLRIVP
     AIPLSGPGPA AANTAVSQGE EPVGYLNMAF SAPPPSSPLS SRGVEDMSHQ RPTCHNPTMR
     REQDRLDTFH SWTLSIIMPA ELAKAGFYYL GQGDRVACFS CGGQLSNWEP GDRALSEHQR
     HYPNCRFVRG DRADNVSLAG AAATASLAAN SQMSSGATVL TNVSNPAMQQ SEERLLTFVN
     WPSRIPVRPE QLAKAGFYYV GRNDDVKCFC CDGGLRCWES GDDPWVEHAK WFPRCEYLLQ
     EKGQDFVHQI QARFPRLFEQ LLTNGDNNSR EFVDPPVVHL GPGEERSEDA VMMNTPVIKS
     ALEMGFERSL VKQTVQSKIL TSGENYRTVQ ELVSDLLSAE DQKREEEREM LAEAMASDGF
     TFVKRHQAAL IQRLKSVEPL FEHLRDQNVL SAEEYSGLLA QTSAQQQTAR LIELILTKGN
     AAAEVFRNWI QKNDVHLLRD LMAQSNEAAS PSQDLSDLPM EEQLRRLQEE RTCKVCMDKE
     VNIVFIPCGH LVVCKECAPS LRKCPICRGL VKGTVRTFLS
//