ID   A0A3P8QPJ4_ASTCA        Unreviewed;       408 AA.
AC   A0A3P8QPJ4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=Rap guanine nucleotide exchange factor (GEF) 5a {ECO:0000313|Ensembl:ENSACLP00000031413.1};
GN   Name=RAPGEF5 {ECO:0000313|Ensembl:ENSACLP00000031413.1};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000031413.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000031413.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000031413.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8QPJ4; -.
DR   STRING; 8154.ENSACLP00000031413; -.
DR   Ensembl; ENSACLT00000032152.1; ENSACLP00000031413.1; ENSACLG00000021311.1.
DR   GeneTree; ENSGT00940000155137; -.
DR   OMA; KLVACHR; -.
DR   Proteomes; UP000265100; Chromosome 22.
DR   Bgee; ENSACLG00000021311; Expressed in brain and 5 other cell types or tissues.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF26; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 5; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168}.
FT   DOMAIN          172..407
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
SQ   SEQUENCE   408 AA;  46912 MW;  3BA2514A14AC0B5C CRC64;
     MKTLYRCVLE DLYEFPILEK DLKEFQKLLR RRHTVDDCPP NQKSKQTYQH MSLKENCLQL
     RSPQTDTREV ICCVYVSADS YLSVHTHPSL EARELLRIVA LKMDRAEEDM VLAVVSHTGE
     RRVLQPSDCV YSESLTPQGK LVACRRDLTE ILPPLTDSAE LSRRPVRLLG INTWDVAAAL
     THLDWSLFKS IHEQELVYYT LSRAPGTGHT AALSVLLQRC NEVQQWVMSE VLMCVSLNKR
     VQLLKKFIKI AAHCKAQRNL NSAFAIIMGL NTAAVSRLNQ TWEKCPGKFK KLFSELELIT
     DPSLNHKAYR EAFKRMKPPK IPFMPLLLKD ITFIHEGNKT FHDNLVNFEK LHMIADTVRM
     IRHCQSDQSG NEVIGVDSAE VRASVHYLHI IDNQQTLFEL SHKLEPRA
//