ID   A0A3P8QPJ7_ASTCA        Unreviewed;       859 AA.
AC   A0A3P8QPJ7;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Eukaryotic translation initiation factor 4 gamma 2 {ECO:0000256|ARBA:ARBA00040449};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000031056.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000031056.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000031056.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Appears to play a role in the switch from cap-dependent to
CC       IRES-mediated translation during mitosis, apoptosis and viral
CC       infection. Cleaved by some caspases and viral proteases.
CC       {ECO:0000256|ARBA:ARBA00037759}.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC       {ECO:0000256|ARBA:ARBA00005775}.
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DR   AlphaFoldDB; A0A3P8QPJ7; -.
DR   Ensembl; ENSACLT00000031784.1; ENSACLP00000031056.1; ENSACLG00000021001.1.
DR   GeneTree; ENSGT00940000154675; -.
DR   Proteomes; UP000265100; Chromosome 7.
DR   Bgee; ENSACLG00000021001; Expressed in ovary and 8 other cell types or tissues.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   CDD; cd11559; W2_eIF4G1_like; 1.
DR   Gene3D; 1.25.40.180; -; 3.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045208; IF4G.
DR   InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   InterPro; IPR003307; W2_domain.
DR   PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR   PANTHER; PTHR23253:SF82; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2; 1.
DR   Pfam; PF02847; MA3; 1.
DR   Pfam; PF02854; MIF4G; 1.
DR   Pfam; PF02020; W2; 1.
DR   SMART; SM00515; eIF5C; 1.
DR   SMART; SM00544; MA3; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; ARM repeat; 3.
DR   PROSITE; PS51366; MI; 1.
DR   PROSITE; PS51363; W2; 1.
PE   3: Inferred from homology;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          496..619
FT                   /note="MI"
FT                   /evidence="ECO:0000259|PROSITE:PS51366"
FT   DOMAIN          673..856
FT                   /note="W2"
FT                   /evidence="ECO:0000259|PROSITE:PS51363"
FT   REGION          443..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        445..474
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   859 AA;  98223 MW;  8AE7524FDB0D0AD2 CRC64;
     MLEQLRISLY PPQIEILCQY TQSLALYFYS EFLGKTPGQS VQRWVPSRST RRDVNSSNEK
     ERHDAIFRKV RGILNKLTPE KFDKLCLELL NVGVDSKLVL KGIILLIVDK ALEEPKYSSL
     YAQLCLRLAE DAPNFDGTSP DIQTPQKQST TFRRLLISKL QDEFENRTRN VEIYDKHDNP
     LTSEEEEQRA IAKIKMLGNI KFIGELGKLD LIHESILHKC IKTLLEKKKR VQLKDMGEDL
     ECLCQIMRTV GPRLDHEKAK SLMDQYFGRM RSLMNNKELP ARIRFLLQDT VELRENNWVP
     RKAFIDNGPK TINQIRQDAV KDLGVFIPAP MSQGMRMDFF LESPFMPSRM KLDRETLGGL
     ADMFGQMPGS GIGTGPGVIQ DRYSPTMGRH RTNPLFNGHG GHIAPPPQSQ FDMGPKSFVK
     SNQISLRPAQ SFLLNKNQVP KLQPQIPTMM PPSAQPPRTQ TPPLGQPPQL GLKTNPPPIQ
     EKPQKTNKKP PPAKEELLKM TEAIMTEYLN TKNLTEAVSG VREMKAPKHF LPEMLSKIIV
     CSLDCPDEDK EHASTLIHTL RTEGLITGEN FMQAFLNVLD QCPKIEVDVP LVKSYLAQFA
     ARAIIAELVS VAELAHPLEN GTHFPLFLLC LQQTAKLKDR EWLTDLFQQS KVNMQKMLPE
     IDQNKDRMLE ILEGKGLSFL FPLLKLEKEL LKQIKADPSP QSIYKWIKDN ISPKFHTDKG
     FVNILMTSFL QYISQELCEA EGDEQLAAPS KEMLEQEKQL LLAFKPVMQK FLHDHTELQV
     SALYALQVHC NARGFPKGML LRYFVNFYDM EIIEEEAFLA WKEDITQEFP GKGKALFQVN
     QWLTWLETAE EEESEDDAD
//