ID A0A3P8QQ22_ASTCA Unreviewed; 546 AA.
AC A0A3P8QQ22;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=T-box transcription factor 4 {ECO:0000313|Ensembl:ENSACLP00000031087.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000031087.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000031087.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000031087.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR STRING; 8154.ENSACLP00000031087; -.
DR Ensembl; ENSACLT00000031783.1; ENSACLP00000031055.1; ENSACLG00000021048.1.
DR Ensembl; ENSACLT00000031817.1; ENSACLP00000031087.1; ENSACLG00000021048.1.
DR GeneTree; ENSGT00940000158882; -.
DR OMA; QYHSGVG; -.
DR OrthoDB; 5323209at2759; -.
DR Proteomes; UP000265100; Chromosome 14.
DR Bgee; ENSACLG00000021048; Expressed in camera-type eye.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
DR GO; GO:0035119; P:embryonic pelvic fin morphogenesis; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20189; T-box_TBX4_5-like; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF29; T-BOX TRANSCRIPTION FACTOR TBX4; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 57..237
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 546 AA; 60623 MW; 4AE810FEA3BF900D CRC64;
MLQEKASTVT DEHVSRLQTG GETDLLPDQS RLGLSTAPTV PSSTEPDQNI ENIKVVLHER
ELWKKFHEAG TEMIITKAGR RMFPSYKVKM TGMNPKTKYI LLIDVVPADD HRYKFCDNKW
MVAGKAEPAM PGRLYVHPDS PATGAHWMRQ LVSFQKLKLT NNHLDPFGHI ILNSMHKYQP
RLHIVKADEN NAFGSKNTAY CTHVFHETAF ISVTSYQNHK ITQLKIENNP FAKGFRGSEE
GDLRVSRLQG KEYPVISKNM VRQRLISTHS HLAGKLGAGV LAGHPQVLSS YQYDTGVPLS
NPDSQDPIST HFPQSRDPNL LYHCFKHRDN GRHLELGCKR SYLETSTAVS DEHYFRSPPS
YESPLLSHPY RTEAITSREA CMYGGMETES GSGAADADDL TNSPSINCNM WATVQPYPRY
GMEGVPYQPF TAHFTNSATV APVVPHPASS VVSRPQADLG VYNSAAVQRG LPVIPPSTSS
SSSSPSFPGS RDSSGHPPLY HRKPGSPLLP HRDFSSYSTQ GTISIREQAY QYQVGLSSTG
SNWTDS
//
