ID A0A3P8QQM0_ASTCA Unreviewed; 2452 AA.
AC A0A3P8QQM0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Fibronectin {ECO:0000256|ARBA:ARBA00020368};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000031406.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000031406.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000031406.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 8154.ENSACLP00000031406; -.
DR Ensembl; ENSACLT00000032145.1; ENSACLP00000031406.1; ENSACLG00000021227.1.
DR GeneTree; ENSGT00940000155126; -.
DR OMA; MCYDAFT; -.
DR OrthoDB; 5399734at2759; -.
DR Proteomes; UP000265100; Chromosome 1.
DR Bgee; ENSACLG00000021227; Expressed in liver and 7 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR GO; GO:0003181; P:atrioventricular valve morphogenesis; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0003128; P:heart field specification; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR CDD; cd00061; FN1; 10.
DR CDD; cd00062; FN2; 2.
DR CDD; cd00063; FN3; 16.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 12.
DR Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 17.
DR InterPro; IPR000083; Fibronectin_type1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013806; Kringle-like.
DR PANTHER; PTHR46708:SF8; FIBRONECTIN; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR Pfam; PF00039; fn1; 11.
DR Pfam; PF00040; fn2; 2.
DR Pfam; PF00041; fn3; 17.
DR PRINTS; PR00013; FNTYPEII.
DR SMART; SM00058; FN1; 12.
DR SMART; SM00059; FN2; 2.
DR SMART; SM00060; FN3; 17.
DR SUPFAM; SSF49265; Fibronectin type III; 10.
DR SUPFAM; SSF57603; FnI-like domain; 12.
DR SUPFAM; SSF57440; Kringle-like; 2.
DR PROSITE; PS01253; FN1_1; 4.
DR PROSITE; PS51091; FN1_2; 10.
DR PROSITE; PS00023; FN2_1; 1.
DR PROSITE; PS51092; FN2_2; 2.
DR PROSITE; PS50853; FN3; 16.
PE 4: Predicted;
KW Acute phase {ECO:0000256|ARBA:ARBA00022486};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00479}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..2452
FT /note="Fibronectin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018017621"
FT DOMAIN 92..133
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 134..177
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 179..223
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 224..268
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 339..387
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 399..447
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 452..496
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 501..543
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 544..587
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 595..687
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 701..789
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 791..883
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 890..981
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 982..1069
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1070..1157
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1158..1252
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1253..1343
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1344..1438
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1439..1526
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1527..1616
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1620..1710
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1711..1800
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1801..1893
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1894..1983
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1986..2076
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2274..2318
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 2319..2361
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 2363..2403
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT REGION 1102..1123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2062..2094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 344..370
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 358..385
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 404..430
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 418..445
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
SQ SEQUENCE 2452 AA; 271854 MW; 0D12A445F2DD5033 CRC64;
MKGSPLTGLL LALCVSSAVH GLPKKNKRQT GQYQVYPELH DTSAINPVGC EENGRSYRVN
EQWEKPYLGS TLVCTCSGAA GIKCKTKPEV EESCYDKYND RTYQVGETYE RLHERMTWDC
TCIGSGKISC TIAHRCHDGG RSYKIGDTWQ RPHDTGAYML ECVCLGNGKG EWTCKPLGER
CYDNSLAATY AVGDTWEKPY QGWMMLDCTC MGEGNGRITC TSRNRCNDQD TRRSYRIGDT
WTRTDTSGHR LQCVCLGNGR GESKCERHSS GRARVVLTPV RQLELPAERT CRTDSGAYYY
DGQRWIKNQG SKQMLCTCLG NGVSCQEWEA RNQVYGGNSD GQPCVFPFVF MGKTYYSCTS
DGRSDGQLWC STTSDYQRDQ QYSFCTEKNA IVTTRGGNSN GALCHFPFLY SGRNYTDCTT
DGRRDNMRWC GTTYDYDSEQ RFGFCPMAAH EEVCTTSDGV MRRVGDKWDK RHDVLGHMMQ
CTCLGNGRGE WNCVAYSQLL DQCIVDGLTY EVNQEFTKRH DQGYMMNCTC FGQGRGYWKC
DAIDQCQEPQ TRTFYQIGET WDKAIHGIYY RCYCYGNGIG EMRCEPQQTY QDGRRPIQVI
ITEAGKQSDS RPIQWNAPSS VQITQYILKW RVKNTRSPWR EVTIPGNINS YTISGLRPGI
TYEGQLISIQ NYGRREVTRF DFTTNLGSLE TYEGETTAPP PVLDTSESVT EITSNSFVVS
WTSADTTISG FRVEYELSEE GSQPKVLDVP RTSTSVTISN LLPGRRYNVS VFEVPSRGQP
NLILTTSQTT APDAPTRHVV NEVGETSIQI SWSRPQAPIT GYRVVYTPSV EGSSTELTLP
ESETSVTLVD LRPGLLYNIS IYAVEEDQES EPVFVQVNTA GSPTQEVVQA PTDLQFYEVS
DTKVTITWTG PPNEVSGYRV TFSPVGSDGT DVRPLGLPVS TSAYSEITHL QPGTLYRFYV
YAINGGVESE PLVGEKATKP DAPTDVRFTE IGPDSALIVW EAPRAIVSGF RLYLSIEGSS
PIEKRIPGRV TQYLLRNLRP DTEYTATLYS DLENELSEGV TTYFTTAPQM GNAPTFSTEV
TDTSIIVTWI PVHRFSYKLS VLPSEEGESP REETSSSGRV YVDGLTPGTQ YTYSVQPIYN
GQNRGNPITR NVVTSLSPPT DLRLESNPNT GVLTAYWVAS KTPGITSYRV TSRPTNGQRG
YSLEEIVAVD QTSVVLEHLT LGMEYNISVF ATKDNVESSP VSTIVTTDIP APSQIDFVDV
TDTTIGLRWI PLNSTTIIGY RIVVVASGQS LPIFQDMVEA SAGYYTIRGL EPGVDYDISI
FTVTEEGDSE PATHTKQTHA AIPAPTNLQF GGVGPDHIRV TWSVPRIATP NDISRFVIRY
HPVSTDNDIK EVNVGGATNT YLLQNLQPNT DYRISVVCVY GERESRPATG TQKTTLDSPT
GLDFSDIRTD SFTVHWQAPQ ARITGYRIRY QKTSGGHAKD ERLPPTRTHY TLTGLSPETE
YMIYVYAVSS SQESQPLTGT QATISDSPTD LVVTRSTPTA VTIRWDAPSI SVRNYRITYA
GTSGETPREI NVPGTQTTAT ITGLNPGTEY TITVYAISGR GDNPATSVPV YITHRTDIEA
PPDMRVADIS DNAITVRWSP ARGPIRGYRV TSIPKNGVGP SYSEDLAPDQ TEVTFTGLMP
TAEYLVSVYA LGNNGQPSSP LIENAVTAMD RPKELTFSDI DSTSMRISWD SPDGAVTSYR
VLYTSAEEGE RELRPAPRGD QDSVVLRNLR PGTEYTVKVI ALHDRAPSSP LVGTQATVIP
APTNLAISEV SPSSFTVSWR APDARLTGYR VVVSPKNINS PHREMNVAPD TTRVVVPGLM
VATTYQVQVY ALKNTVTSRP AEAEATTLQA LSAPRRVRVI KVTDSSFTLT WRSKLEPFTG
FLIEAIPQSG SYPTITKTIP SEAYTYTLTG LRPNTVYNVN MYTLSGNTRS DPFTLRIQTV
DPLVQAPTNL QFTSVTPYSI SFTWQPPATQ ITGYYVTYEE SGGRPQELFP RPHAGQNYAT
IDDLRPDTEY IIKIIAIQNT QRSTPLVGRS RTPQDPLLPL PLPQPNRPGN GRLDVPESLD
NNVQLVGTNS QDGFGDQSQH VEYTEYNNNG DNGYNRNPLS PYGQVREPLV FVPLPDAEGR
RKPIVKLNMP IGPILFNETS VPLEAQTQTT VSWKPYRQSN AYLVSCHPIT QLNEKMFQVR
LPGTATTATL LGLTPGADYN VIVEALLGAL KHKILEQTVT AGNTITEGDS SNKDTCYDAF
TATHHDVGAE WERMSETGFK LSCRCLGLGS GHFRCDSSKW CHDNGNNYRI GEKWDRRSEN
GNLMSCTCLG NGKGEFKCEP HESTCYDDGK TYRVGNQWQK EYLGSICTCT CFGGQQGWRC
ENCRRPGGDV DVGLLQPIRY GDNTLRKNIH CPIECLRPEL LADAHVPHNP RE
//
