ID A0A3P8QTL4_ASTCA Unreviewed; 1024 AA.
AC A0A3P8QTL4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Synemin {ECO:0000313|Ensembl:ENSACLP00000032262.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000032262.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000032262.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000032262.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; A0A3P8QTL4; -.
DR STRING; 8154.ENSACLP00000032262; -.
DR Ensembl; ENSACLT00000033024.1; ENSACLP00000032262.1; ENSACLG00000021881.1.
DR GeneTree; ENSGT00940000159268; -.
DR OMA; KMLYASE; -.
DR OrthoDB; 5353519at2759; -.
DR Proteomes; UP000265100; Chromosome 7.
DR Bgee; ENSACLG00000021881; Expressed in muscle tissue and 4 other cell types or tissues.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0008307; F:structural constituent of muscle; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR030634; SYNM.
DR PANTHER; PTHR47136; SYNEMIN; 1.
DR PANTHER; PTHR47136:SF1; SYNEMIN; 1.
DR Pfam; PF00038; Filament; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}.
FT DOMAIN 11..318
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 362..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 8..49
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 111..152
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 202..331
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 411..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1024 AA; 115937 MW; ACE0695B10BAC2AA CRC64;
MLPFKRTFES EKHQLQELNS RLTQYLSRTK QLEQENAHLI AEINKLRQVR TTGWETKYRA
EMQDLRRMVG QLSFEKSQAE MEREKLWREL QMIQSLCSEQ TDVCRDVSGE LKNCEQELHH
AHKTNSELQQ RLLQLENEYK RLEDAHREEV SRLCSQVESR VAPIIRQTYR GPPVVSVEEV
QEYAHGMSEG WIQTFEMYQK TVEDMEQSIK ADQAMLNDMQ REKMLYASEL DKLRTEAEKQ
GQIQMRLEEQ LMHMQEKFRV DYSQYQMTIE QLEHERNVMA DVIAQKMREH QQLLQVKMDL
GMEVATYRAL LEGERISLQD AHKRVNQHQR ERIIDIKMPA RRYTPRASTL TTKQHMDVRY
MPSTSSLRRA PIPSSGSISP SRVIPISVTG RARHQSPASR RDMISFNKAR AAASASATTI
TTTSTTTKDK QAGHSENQVS RSVPKRTAEE QTVKLIWLPH TEGQMSPDKS STPDTKSVRV
VSPSMKSLVT ETETESKKYV SDEKEKGPVV DGKVKDKGRT EFTIGPAEKK ILDSVSVEEI
IEKVIKPAGL EAKVCSAGDS KVRYHVEKTE QEDGTTKTQI VLESKVEEEL DVSQDNALEE
LLKQGVKKVS LEDIKDTATG SMVKNLLSGL QGGEDLQNKS VNVEIIEEPV ESYSDEELEA
EQKSGLTFHE PSAYFEVEEP ENIPHGIQGS RGDDNVMKSN TDESKFGSVQ VQEVSRESEY
PHFSHDQESH EYFVSTPDEN LSESEEGGGI TSYGHYGIVD DLSDERYYQD DGLPQKKVTV
KESDEYEFMS GDRLFAKESF PECIIEEEVR VSPVVQESVL EYLREDSLEP KEQLKGALEK
LQSSVSGPLK EELAFLTRVS SESPENVAVG VKRVEQSTDN GTMTIVAELN VSQTLEESGL
LEGDDLSEDQ IMAALKSSNI GIEKAFQSGA GGGYSIRVSR EDNVAHSVDY GDFSDKGESA
SEISEKHFKL GPSDKSFSFQ MDVHGGHDEA ASEQELQPPV LEMPVKISQE KRIATVYLES
PSND
//
