ID   A0A3P8R0G9_ASTCA        Unreviewed;       760 AA.
AC   A0A3P8R0G9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Cullin 4A {ECO:0000313|Ensembl:ENSACLP00000035328.1};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000035328.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000035328.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000035328.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   AlphaFoldDB; A0A3P8R0G9; -.
DR   STRING; 8154.ENSACLP00000035328; -.
DR   Ensembl; ENSACLT00000036159.1; ENSACLP00000035328.1; ENSACLG00000023869.1.
DR   GeneTree; ENSGT00940000156905; -.
DR   OMA; NVVQSCF; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000265100; Chromosome 1.
DR   Bgee; ENSACLG00000023869; Expressed in ovary and 8 other cell types or tissues.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0035118; P:embryonic pectoral fin morphogenesis; IEA:Ensembl.
DR   GO; GO:0007507; P:heart development; IEA:Ensembl.
DR   GO; GO:0071600; P:otic vesicle morphogenesis; IEA:Ensembl.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF68; CULLIN-4A; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          405..633
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   760 AA;  88522 MW;  2915E4165ECBC261 CRC64;
     MAEDTRQDKR ASFSITEHSA NGMARTSAVA SGKTGTSKKL VIKNFKDRPK LAENYTEDTW
     LKLRDAVGAI QNSTSIKYNL EELYQAVENL CSYKVSPTLY KQLRQVCEDH VQAQIHQFRE
     YPFLCSLDNL SFLKRMNRCW QDHCRQTIMI RSIFLFLDRT YVLQNSLLPS IWDTGLELFR
     THIVSDSAVQ KRTVEGILEQ IELERNGETV DRSLLRSLLG MLSDLQVYKD SFEERFLTET
     NRLYAAEGQH LMQERDVPEY LHHVARRLEE ENDRIVSYLD QSTQKRLISC VEKQLLEEHM
     TAILQKGLST LLDENRVTEL TLLYQLFSKV KGGLPTLLQF WRDYIKSFGG EIVCTPEKDK
     DMVQDLLDFK DKMDNVAQSC FARNESFINA MKEAFETFIN KRPNKPAELI AKYVDSKLRA
     GNKEATEEEL ERILDKIMII FRFIHGKDVF EAFYKKDLAK RLLVGKSASV DAEKSMLSKL
     KHECGAAFTS KLEGMFKDME LSKDIMIQFK QYMQNQSEPS NIELTVNILT MGYWPSYTPM
     EVHLPTEMVK LQEVFKLFYL GKHSGRKLQW QPTLGHAVLK AEFKEGKKEL QVSLFQTLVL
     LMFNEGEEFS MEEIRAATGI EEGELKRTLQ SLACGKARVL NKNPRGKDVE DGDRFNFNND
     FKHKLFRIKI NQIQMKETVE EQVSTTERVF QDRQYQIDAA VVRIMKMRKT LSHNLLVSEL
     YNQLKFPVKP GDLKKRIESL IDRDYMERDK ETPNQYHYVA
//