ID A0A3P8R124_ASTCA Unreviewed; 653 AA.
AC A0A3P8R124;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Cationic amino acid transporter 2-like {ECO:0000313|Ensembl:ENSACLP00000034941.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000034941.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000034941.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000034941.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143,
CC ChEBI:CHEBI:32682; Evidence={ECO:0000256|ARBA:ARBA00034423};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine(in) = L-lysine(out); Xref=Rhea:RHEA:70935,
CC ChEBI:CHEBI:32551; Evidence={ECO:0000256|ARBA:ARBA00034422};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-ornithine(in) = L-ornithine(out); Xref=Rhea:RHEA:71199,
CC ChEBI:CHEBI:46911; Evidence={ECO:0000256|ARBA:ARBA00034450};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
CC {ECO:0000256|ARBA:ARBA00008572}.
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DR AlphaFoldDB; A0A3P8R124; -.
DR Ensembl; ENSACLT00000035768.1; ENSACLP00000034941.1; ENSACLG00000023618.1.
DR GeneTree; ENSGT00940000168334; -.
DR Proteomes; UP000265100; Chromosome 2.
DR Bgee; ENSACLG00000023618; Expressed in liver and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0061459; F:L-arginine transmembrane transporter activity; IEA:UniProt.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR004755; Cat_AA_permease.
DR InterPro; IPR029485; CAT_C.
DR NCBIfam; TIGR00906; 2A0303; 1.
DR PANTHER; PTHR43243:SF35; CATIONIC AMINO ACID TRANSPORTER 2; 1.
DR PANTHER; PTHR43243; INNER MEMBRANE TRANSPORTER YGJI-RELATED; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..577
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 556..606
FT /note="Cationic amino acid transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13906"
FT REGION 617..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..644
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 653 AA; 70807 MW; 7D8C37A564849B53 CRC64;
MLKQVLSFSR SLVRRKVVDL NSLEDSKLCR CLGTLDLIAL GVGSTLGAGV YVLAGEVAKG
DSGPSIVISF LIAAMASVMA GLCYAEFGAR VPKTGSAYLY SYVTVGEIWA FITGWNLILS
YVIGTSSVAR AWSGTFDEMI GGHIEIFCKT HFSMNSPGLA QYPDFFAVCL ILLLSGLLSF
GVKESAWVNK VFTSINVLVL LFVIISGFVK GDAYNWKITE DSLINVTIAT RNLSVTANVS
SDYGVGGFMP YGFSGTLAGA ATCFYAFVGF DCIATTGEEV KNPQRAIPTG IVVSLTVCFL
AYFGVSAALT LMMPYYLLDE KSPLPMAFEY VGWGPAKYVV AVGSLCALST SLLGSMFPLP
RILFAMARDG ILFKFMSKVS KRQSPVAATM AAGTTAAIMA FLFDLKALVD MMSIGTLLAY
SLVAVCVLLL RYQPDGALER QASKGERDCL ASEEGESDLT ESESHLNMLK GGSSTLQTIL
HPPETPSECS SSVVNMSTGV LVLVVCVISY LTTYHINSVL GLEVWILASL SVCLLVFSSC
IFMVIRQPQT KKEVSFMVPL LPFLPILSIF VNIYLMVQLS GDTWIRFSVW MAAGFLIYFG
YGVWHSVERQ RQLQLQSGTA QENTRSNQEK RDNVDAEGKE QESFICSEKT SQC
//