ID   A0A3P8R309_ASTCA        Unreviewed;       893 AA.
AC   A0A3P8R309;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Holocarboxylase synthetase {ECO:0000313|Ensembl:ENSACLP00000036305.1};
GN   Name=HLCS {ECO:0000313|Ensembl:ENSACLP00000036305.1};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000036305.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000036305.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000036305.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the biotin--protein ligase family.
CC       {ECO:0000256|ARBA:ARBA00009934}.
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DR   AlphaFoldDB; A0A3P8R309; -.
DR   STRING; 8154.ENSACLP00000036305; -.
DR   Ensembl; ENSACLT00000037165.1; ENSACLP00000036305.1; ENSACLG00000024603.1.
DR   GeneTree; ENSGT00390000002960; -.
DR   OMA; VEHCPLH; -.
DR   OrthoDB; 317678at2759; -.
DR   Proteomes; UP000265100; Chromosome 10.
DR   Bgee; ENSACLG00000024603; Expressed in testis and 6 other cell types or tissues.
DR   GO; GO:0004077; F:biotin-[acetyl-CoA-carboxylase] ligase activity; IEA:InterPro.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   CDD; cd16442; BPL; 1.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004408; Biotin_CoA_COase_ligase.
DR   InterPro; IPR004143; BPL_LPL_catalytic.
DR   NCBIfam; TIGR00121; birA_ligase; 1.
DR   PANTHER; PTHR12835; BIOTIN PROTEIN LIGASE; 1.
DR   PANTHER; PTHR12835:SF5; BIOTIN--PROTEIN LIGASE; 1.
DR   Pfam; PF03099; BPL_LplA_LipB; 1.
DR   SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR   PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598}.
FT   DOMAIN          621..819
FT                   /note="BPL/LPL catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51733"
SQ   SEQUENCE   893 AA;  98719 MW;  B29E216D1BEA2C8D CRC64;
     MLITLCYVYM WVRFHRCYSA LIRSGLNSSS FSFSLCSRRA ARARSGSLQL EDNVFLQRGD
     KAVYVSEPQV CEDLSQWTVL LRSSTVCAPR IDNIFFIIEA TEHKVGSPSH RPSKKKVLKL
     SDCCLPVACC PGQPFRAVAR ASVESYSQLG IAFIEDRLQL DNGLTPSKIV PVLLQESTLS
     ALLDQQCPQS PRAQSSLLPC STGEPIARHH HLQCRKGSFL LIPEVKRRLE DRRGSEPLRS
     SQDLESLGDL EEHSLGNHHH MEGHGHHLHL SSCHECLELE NSTILSVKYA SAENIPDLPD
     DNSVGNKCLD ELENDSRGFF GQSGGKLPNV LVYTGGCQER FQTVRQLLSE CINTESNIIY
     PLQPEQALND PWLENTRLLV LAEEETLSPQ LQTRFLTYLS QGGKVLGLAS SLCPAGLYLE
     VRQSQCMQVN KLNFTKEDST ELNLSILASG KVYIRDPRGG GEVELWGELK GDVPHKKDMV
     IVRLTHGGDS GEAVLCQVHF ETAPNSQNLP LDAFDELKVN NASRYEVLTE ILTSLGLKCE
     PSQTPSPSAV HLLATSQEAK ARFLKWLQAH AEHNGVLTLS KASLVMMSGS DLQDALLLPE
     GSVALVTNSA ESQSWAHFSM ETYSKNLKTK LLGHTVLFAE IVTSTMDLLE GLTVHLPRDM
     GLLVVATQQS QGRGRGRNAW LSPLGCAMFT LNVQIELNSK LGQRIPFLQH LVALAVVEAV
     CSLPGYQDID LRVKWPNDIY YGNLMKLGGV LVTSTVLGST FHLLIGCGFN VTNSNPTVCI
     NDLIQSYNLQ HNCSLQPLSC AQLIARTVNC LEALIDNFQQ GGPESVLPTY YKRWLHSGTW
     VRLWSEDGPE VQVMGLDHNG FLQVHSKEQG VVSVEPDGNS FDMLKNLVVI KTH
//