ID A0A3P8R5I9_ASTCA Unreviewed; 1144 AA.
AC A0A3P8R5I9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=WW and C2 domain containing 1 {ECO:0000313|Ensembl:ENSACLP00000037205.1};
GN Name=WWC1 {ECO:0000313|Ensembl:ENSACLP00000037205.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000037205.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000037205.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000037205.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8R5I9; -.
DR STRING; 8154.ENSACLP00000037205; -.
DR Ensembl; ENSACLT00000038086.1; ENSACLP00000037205.1; ENSACLG00000025210.1.
DR GeneTree; ENSGT00410000025556; -.
DR OMA; QVTVVSM; -.
DR OrthoDB; 1334597at2759; -.
DR Proteomes; UP000265100; Chromosome 10.
DR Bgee; ENSACLG00000025210; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0071599; P:otic vesicle development; IEA:Ensembl.
DR GO; GO:0032475; P:otolith formation; IEA:Ensembl.
DR CDD; cd08680; C2_Kibra; 1.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037771; C2_WWC.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR14791; BOMB/KIRA PROTEINS; 1.
DR PANTHER; PTHR14791:SF22; PROTEIN KIBRA; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}.
FT DOMAIN 6..39
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 53..86
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 700..825
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 134..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 979..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 107..134
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 367..394
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1035..1100
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 135..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..529
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..644
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..884
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1144 AA; 127819 MW; F9790540568025F3 CRC64;
MPRKELPLPD GWEEARDFDG KVYYIDHINQ CTSWIDPRDR QTKPLTFADC IGDELPVGWE
EAYDPVVGAY YVDHNTKSTQ LEDPRAQWQR EQEAMLRDYL AVASDALSAQ KEIYQVKEQR
LRLAQQEYRQ LNDAWRDKST SQTSLNSRSS SSSKYDPDIL KAEISTAKSR VNKLKRDLAC
MKQELLYKEQ GFETLKEIDQ KVSNSPSGYR LQEAQAILSE VRSIRDAISS GEKEKQELMQ
KLAVLKDGFR LDSGSQQELW GSSTSLANSD LSVPRLYSDA SSQTDIPAEF MTSSNKLAEK
VRVSLKYEEA KRRIATIEVQ IAKLDSEAWP GLLDPERDRL ILINEKEELL KELQYISPRQ
RLQPNDAEKL ESEKKRLERD LQAARDNQSK ALTERLRLHC KRNKLVRELE ENVRLATMLH
TQLKSLSAST LSCSSGSSRG SLTSSRGSLA TTSSLGSTSS LSFTDIYLEQ PELADPDFQN
KLDSLLQEGV QGGYRPSSSI TTIHEHEVVT GSGTKDAGRP QSKSGGTGGD TGGGTGAGVG
AEPSRIQALK LSETPRSMNS LSPRSSLSSL SPPCSPLVTD ATFLSGETFA GQSGGSGLGL
DLELHSRLAE LELRLDSEEQ RQEEQGGPEE KQNHHGRLGE EVKGSASELR GTGAGPKKIG
VTSAVSDESV AGDSGVYEPS ERKPGLPADL LLSSYEDRLA PGCPQVQLGF RYEARDRRFT
VYVMQLSNCS ALCLPTDQKM YVRVAVLPCV EATRCLFRTR SSPPRDAVEF NEVFGMQISH
SALRQKTLRV DVCDTGKSGH EECLAGAQIS LADVSCSEEK CTKWYNLLSR VYLPETHVSS
GDRAGGPEDD EWHGEPLEAD MFEDDEGHGT EGAGPLKDED EFYPESSQWE AEEEEDEEKG
PKPPPPPTAV AAAAITEKVN KETSMDSLPS LHHCSVVRPK ERRPDVRQQN PFMRGNTIIR
SKTFSPGPQS QYICRINRSD SDSSTLSKKS PFVRNASERR SMRMKRPPVP VKGLDGLLRT
SLDLELDLQV SRTRQARLAQ ELRVLRELKT QLEKARQQGQ KELPAWVQED ERFRLLLRQA
EKQTREEQQQ EKRVEKMMKA AAKDVHKIRG QSRKEVPEVQ TFREKMAFFT RAKTCIPDLP
ADDV
//
