ID A0A3P8R6W7_ASTCA Unreviewed; 1998 AA.
AC A0A3P8R6W7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Dedicator of cytokinesis 3 {ECO:0000313|Ensembl:ENSACLP00000037209.1};
GN Name=DOCK3 {ECO:0000313|Ensembl:ENSACLP00000037209.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000037209.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000037209.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000037209.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 8154.ENSACLP00000037209; -.
DR Ensembl; ENSACLT00000038090.1; ENSACLP00000037209.1; ENSACLG00000025127.1.
DR GeneTree; ENSGT00940000155514; -.
DR OMA; CADPHMN; -.
DR Proteomes; UP000265100; Chromosome 20.
DR Bgee; ENSACLG00000025127; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08695; C2_Dock-B; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR InterPro; IPR037811; C2_Dock-B.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF4; DEDICATOR OF CYTOKINESIS PROTEIN 3; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 386..564
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1182..1589
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1629..1671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1777..1855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1886..1998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1629..1661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1806..1837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1906..1920
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1933..1948
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1972..1998
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1998 AA; 230901 MW; ACE9FA146549E6BA CRC64;
LEIGETVQIL EKSEGKISPV SYGIFPVSYV HLKKSTVTNR GLCETVVPLE DPIITETTST
LQEWGVLWKQ LYVKHKVDLF HKLRHVMNEL IDLRRQLIQG HLAQDQTREI KRHITVRLDW
GNEHLGLDLV PRKEFEMVDP DQISVSELYK LHVSSRHCGQ QSTNQVRQRH GDGCRVPVSH
HLFINLKSFT YNSISEDADV FFSLYDSREA KQISEKFMVK LNKNGGPKNP EKVDRLCALF
TDLSSKDLKR DLYIVAHVIR TGRMLLNDSK KGPPHVQYRR PYGCAVLAMS DVFHTITDLK
EEKDFVLKVY TCNNENEWYQ VHENIIRKSN TKYSAPSTNY GLIISLQLLR GELEQIRREN
QAVFNRALAL TRKLGFPDVI LPGDTRNDLY LTLERGEFER GGKSVQKNIE VTLYVLYADG
DTLKDCISLG SGEPNTSEYR SFVLYHNNSP RWSEMVKLPI PIDRFRGSHL RFEFRHCSTK
DKGEKKLFGF AFTPLMREDG TTLSDESHEL YVYKCDENAT FSNQGLYLSL PCCKEDFNSC
PNLPANLPFQ RSPKETFWVS TILCSTKLTQ NVDLLALLNW KAHPDRVLDI LGRLRQISGE
EIVKFLRDVL DTLFCLLDDN TDKYGPLVFQ SLVFIINLLR DSRFYHFRPV MDSYIQNHFA
GALAYKELVR CLKWYMDRSA EVVRQDHIQE AMRALEYLFK FIVQSRILYS RATCGMEEEQ
FRASIQELFQ SIRFVLSLDS RSSENLVFTQ AALLNSFPDI FDELLQMFTV QEVAEYVRGT
LGSMPSTVDI GQSMDVVKLQ SIARTVESRL FFFPESRSIL LPVVLHHIHL HLRQQRELLI
CSGILGSIFS IIKTSSMESS VQEEVEMMVE SLLDVLLQTL LSIMSKSHSV ETSRGQRCPQ
CTAEITGEYV SCLLSLLRQM TEIHFHHLLN NFHSKEELKE FLLKIFCVFR NLMKLTIFPR
DWSVMRLLTS HIIVVTTQFL SPALHKNFSD ADFDFKVWNS FFSLTVLYIN QPSLQLESLG
PAKRKKVLDK YGDMRVMMAY ELFSMWQKLG DNKPHFIPGM MGPFLGVTLV PQTEVRNIMI
PIFHDMMDWE QRKNGNFKQV EAELMDKLDS MVSDGKGDDN HRELFSLLTQ LFGPYPSLLE
KIEQETWRET GISFVTSVTR LVERILDYRD CMKGDEMENK KIGEVNKEDM YIRYIHKLCD
LHLQAEDFTE AAFTLLLYWE LLQWEDRPLR DFLHYPCQSE WQRKENLSRK ILHYFNKGKC
WEYGISLCRE LAFQYETLYD YQSLSWIRKM EAAYYDNIIE QQRIEPEFFR MGFYGRKFPF
FLRNKEFVCR GYDYERLEDF QQRMLGEFPQ AIAMQHPNIP DDTILQSDAQ YLQIYAVTPV
SDISDVPQLE RVPERIKSFY RINNVSRFHY DRPFHKGPKD RENEFRSLWI ERTTLILLRP
LPGISRWAEV ERREVVEVSP LENAIYVVEN KTQELRTLIS QYQHRQHHGN INPLSMCLNG
VIDAAVNGGI ARYQEAFFDK DYISSHPEDT ERISHLKDLM QEQVHILGVG LAVHEKLVHP
EMRPLHKKLV DQFHMMRTGL HHVSRVTRDS NYTPSVPESV RLMHRHRSVV VINHWFILQS
TKAQKTNKSF VLQPSPSSSS LSSIRSNSSQ IINSAPSSAR GSPSLPDKAK HNREVMILLP
SHRERANNSM YYNMAENGQN NHMQRALLQQ VSPCKPCTDV HMTLPEKVFP NTPSSWSLDG
ENREQMTYMP ASTGGVIMPP VPPRSFPPGH FLMHCDAFHQ QNSDPPPALP VRSLRKSPLH
PIPGSPTSPQ SALGGSNSTL SGSASSGVSS LSESNFGGQY PDPGPIRNDA LEPLPSHLWS
PPDEYMASPY MHIHYGGGEI DSMDPVRPFH YRSPASHPHN HPHPHAHAHP GLDSHSHGPP
THHHAPTHGP HHIPYRRPQP PAVPPKPYLR EGCIPEEDLP PQPIPLPRRI FHSPHGHRED
QGKHAWEQCI SEEHEETQ
//