ID A0A3P8R7W9_ASTCA Unreviewed; 697 AA.
AC A0A3P8R7W9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Rho guanine nucleotide exchange factor 25-like {ECO:0000313|Ensembl:ENSACLP00000037191.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000037191.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000037191.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000037191.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8R7W9; -.
DR STRING; 8154.ENSACLP00000037191; -.
DR Ensembl; ENSACLT00000038072.1; ENSACLP00000037191.1; ENSACLG00000025197.1.
DR GeneTree; ENSGT00940000154766; -.
DR OMA; PLEMHDN; -.
DR Proteomes; UP000265100; Chromosome 5.
DR Bgee; ENSACLG00000025197; Expressed in camera-type eye and 6 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13241; PH2_Kalirin_Trio_p63RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22826:SF117; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 4B-RELATED; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
FT DOMAIN 238..414
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 426..541
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 43..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 697 AA; 77678 MW; 97366F22CE548CDF CRC64;
MLHSHFFSLA CSLEAPSHPK ECYLSLTLSR METLRYRQGL IPGGGPPLQW PSSSRTAESY
SVAGSDGSIT PSVGSVPHQA SGGSSPCSHS SSGGSRHPVT TLKKWLTNPV RKLSSDARSG
AGKGEKQMFG SDGRQPMLIL SHTETQQRPM EVHNNYTILT SGDTEWKDGL LNPAVHSPLH
PASPSYLSDL LQGRNAQSLS QSINTLQRED SCTVTDDSTS QCSGTVDSEE ERNIALEKSI
YVLTELIETE RLYVEDLGLI VQGYMATMGN QGVPEDLRGK DRIVFGNIHQ IYDWHKDYFL
GELEKCVGDP DSLARLFIKH ERRLHMYVVY CQNKPKSEHI VSEYIETYFE DLRQQLGHRL
QLNDLLIKPV QRIMKYQLLL KDFLKYYSKA GKDVEELQRA VEVMCFVPKR CNDMMNVGRL
QGFEGKITAQ GKLLQQDTFS VSEQESGFLS KARERRVFLF EQLVIFSEPI DKKKGFPLPG
YTFRNSIKVS CLGVEEHSEE DPCCLVLTSR GTDGSVTRFI MQASSPDIQQ AWHSDVVQIL
ETQRNFLNAL QSPIEYQRRE SKSNSLGRNT KSPSTSASGL WPHSSASVDR RQQPCFLSYN
TSLPSMHSSQ HSPASQTVSN PCVVTVCAAH PSLSSPMQLS LCSEVRRDCG TSNGLAPCSY
HSLQGVPASF QTITFKDAGT YSAHQLNNLD QLKESEQ
//
