ID A0A3P8R8T4_ASTCA Unreviewed; 1537 AA.
AC A0A3P8R8T4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Nuclear receptor coactivator 2 {ECO:0000256|ARBA:ARBA00013484};
DE AltName: Full=Transcriptional intermediary factor 2 {ECO:0000256|ARBA:ARBA00031751};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000037457.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000037457.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000037457.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933}.
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DR STRING; 8154.ENSACLP00000037457; -.
DR Ensembl; ENSACLT00000038339.1; ENSACLP00000037457.1; ENSACLG00000025323.1.
DR Ensembl; ENSACLT00000038364.1; ENSACLP00000037481.1; ENSACLG00000025323.1.
DR GeneTree; ENSGT00950000183021; -.
DR OMA; PIMPNAQ; -.
DR Proteomes; UP000265100; Chromosome 9.
DR Bgee; ENSACLG00000025323; Expressed in muscle tissue and 8 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:InterPro.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd18950; bHLH-PAS_NCoA2_SRC2; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 6.10.140.20; Nuclear receptor coactivator, Ncoa-type, interlocking domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR032565; NCOA2/3_DUF4927.
DR InterPro; IPR028822; NCOA2_bHLH.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF2; NUCLEAR RECEPTOR COACTIVATOR 2; 1.
DR Pfam; PF07469; DUF1518; 2.
DR Pfam; PF16279; DUF4927; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR PIRSF; PIRSF038181; Nuclear_receptor_coactivator; 1.
DR SMART; SM01151; DUF1518; 2.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 27..84
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 120..184
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1267..1382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1407..1430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1514..1537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 74..104
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 11..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..664
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 994..1025
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1267..1293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1308..1338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1352..1382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1514..1528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1537 AA; 164981 MW; CAB5EAA952D224A7 CRC64;
MSGVGENSSD PGRAESRKRK ECSAELLGPS PKRSNEKRNR EHENKYIEEL AELIFANFND
IDNFNVKPDK CAILKETVKQ IRQIKEQEKA AAANEEEVQK ADVSSTGQSV IDKDALGPMM
LEALDGFFFV VNMEGNIVFV SENVTQYLRY NQEELMNTSV YSVLHVGDHA EFIKNLLPKS
LVNGVPWSSE GPRRNSHTFN CRMLVNPHGE SQEEPHEHEP QQQKYETMQC FAVSEPKSIK
EEGDDFQSCL ICVARRVPTK ERPMLPAHES FTTRQDLQGK ITSLDTSLLR ASMKPGWEDL
VRRCIQRFHL QNDGEMSFAK RHQQEVLRHG QAFSPIYRFS LSDGTIVSAH TKSKLVRSSA
TNEPQLYMSL HILQREQTVC GMGQDMGPGN QATGMAPKPM NSSTPSMTPP TPGSLPGSGP
QGQDTTISSN STPFSPPGPA GPREPTAMGG HMQVYRFGCP QPHNHNGSMQ PPQQGPNWRM
NSPSRASPSP AGGPHPPPQN SMLSPRHRGS PGGASSPRVA GGLHSPSPVG MCSGGPGGAG
SSTASTHANS YTSSSLSALQ ALSECHGVGH GHGPPHTHTL GSPDRKMGSP AGVTPGSAVN
AHLMSKLGGS TSAIGGSGDS FGPHSEMSQG HTQAQTEGNL VEPKEERDGP LEGHDAHSRG
HDNKGHTKLL QLLTTKPEPL ETPLSPGAGV EGKDQAGTGV RGGNTHATSL KEKHKILHQL
LQNSTSPVDL AKLTAEATGK EMGQDQPQGS GSAASAADIT PKQEPLSPKK KDNALLRYLL
DKDDTVMKDK VPKLEPGEVK VEGGKHPQVK AEKQDAGYDR AEQSSELDDI LNDLQNAQPQ
LFCEPRPVSL PSPMDKQNII NDILQMSESS PVMAAQPQHR GLGPGMGPTN FGGVRPGQPG
RGLSVRSVSL DVNMSPQQPS LQYPIRTTSP YTVMQQQQGM VGNHGMMGNQ AAMVNAALMA
PSGPRPGMQQ QEAWVGPASA PPIGAPGPGH QNAIQGRTGP SGTPMRPNSQ PGPRQMMQSP
IMPNTQPDID IGMVGDHFSQ QQAPPNQTAP WPDSMMPIDQ TAFVNQSRAP PQDDLLCNTG
LSSSDGSAVD EGALMSQLYT ALKDFDGLEE LDRALGIPAM VEQSQSLEPD QFPQEPSVML
DQKPPMYTQQ FGPPASHMAP RGYPGGPMQE PGFHPMPGQM GPRPGFQMMR MPARPGLRPT
GVVPNQPNTL RLQLQHRLQS QQNRQPMMTQ MSGVSNVNLP LRTNAPNQGT INAQMLAQRQ
RELLSNHLRQ RQQQQQQVQQ AQQVQQQRSM AMRAQGLNLP PNMAAGGMSN PRNPQANPQQ
LPYPPSYGTS TSLASSPPPT SSFPSPLSPS LPSLTPNLHL HGTSSSSSTP SSSSQMMMGN
TNMMGGQYGA VLSPQMQHSA FQFPNSGMSQ QADGTFGGPG TPQSPLLSPR MAHTQSPMMQ
QGQQSAAFQG SPDMNGWPQG NMGVNSMFSQ QQASPQFSQP NNSNMYNGNG INLNNASLAS
NMATSSMGQM AGQMSVTSMA SGPSPGLPSM GQEQKYC
//
