ID A0A3P8R8W6_ASTCA Unreviewed; 414 AA.
AC A0A3P8R8W6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=SH3-domain GRB2-like 3a {ECO:0000313|Ensembl:ENSACLP00000038390.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000038390.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000038390.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000038390.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the endophilin family.
CC {ECO:0000256|ARBA:ARBA00006697}.
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DR AlphaFoldDB; A0A3P8R8W6; -.
DR Ensembl; ENSACLT00000039294.1; ENSACLP00000038390.1; ENSACLG00000025916.1.
DR GeneTree; ENSGT00940000157398; -.
DR Proteomes; UP000265100; Chromosome 1.
DR Bgee; ENSACLG00000025916; Expressed in spleen and 7 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd07592; BAR_Endophilin_A; 1.
DR CDD; cd11803; SH3_Endophilin_A; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035824; Endophilin_A_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14167:SF45; ENDOPHILIN-A3; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 18..290
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 352..411
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 414 AA; 46783 MW; 8575B3ED2C60B7C1 CRC64;
MSVAGLKKQF HKASQLLSEK ISGAEGTKLE EDFLEMERKI EVTSKSVLDL LSKTTEYLQP
NPASRAKLNM LNTMSKIRGQ VKTTGYPQTE GLLGDCMLRY GQELGEDSLF GCALVDVGEA
MRQMADVKDS LDINVKQNFI DPLQNLQDKD LKEITHHLKK LEGRRLDFDY KKKRQGKIPD
EEIRQAVEKF DESKELAERS MFNFLENDVR DAKTRVTGRV SHVRRYRLTC VCVRVRVCAC
VCVCVCGHQV EQVNQLSALI KAALEYHQQS CEILQELSGK LQKRISSASS RPKRDFKPKS
IRSSIEALDS NQHNGLSYSS SLKSTADHIS SVQLSWPDTP ATNGNAHQPE VLDQPCCRSL
YDFEPENEGE LGFKEGDIII LTNQIDENWY EGMINGESGF FPINYVEVIV PLPQ
//
