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Database: UniProt
Entry: A0A3P8RB37_ASTCA
LinkDB: A0A3P8RB37_ASTCA
Original site: A0A3P8RB37_ASTCA 
ID   A0A3P8RB37_ASTCA        Unreviewed;      2030 AA.
AC   A0A3P8RB37;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000038191.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000038191.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000038191.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC       excitable membranes. Assuming opened or closed conformations in
CC       response to the voltage difference across the membrane, the protein
CC       forms a sodium-selective channel through which Na(+) ions may pass in
CC       accordance with their electrochemical gradient.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC       ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   STRING; 8154.ENSACLP00000038191; -.
DR   Ensembl; ENSACLT00000039082.1; ENSACLP00000038191.1; ENSACLG00000025753.1.
DR   GeneTree; ENSGT00940000163423; -.
DR   OrthoDB; 1110761at2759; -.
DR   Proteomes; UP000265100; Chromosome 23.
DR   Bgee; ENSACLG00000025753; Expressed in brain and 2 other cell types or tissues.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR   GO; GO:0006110; P:regulation of glycolytic process; IEA:Ensembl.
DR   GO; GO:1904059; P:regulation of locomotor rhythm; IEA:Ensembl.
DR   GO; GO:0002082; P:regulation of oxidative phosphorylation; IEA:Ensembl.
DR   GO; GO:0036269; P:swimming behavior; IEA:Ensembl.
DR   GO; GO:0099536; P:synaptic signaling; IEA:Ensembl.
DR   CDD; cd13433; Na_channel_gate; 1.
DR   Gene3D; 1.10.287.70; -; 4.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   Gene3D; 1.20.5.1190; iswi atpase; 1.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR044564; Na_chnl_inactivation_gate.
DR   InterPro; IPR010526; Na_trans_assoc_dom.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR043203; VGCC_Ca_Na.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF237; SODIUM CHANNEL PROTEIN TYPE 3 SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW   ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM        125..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        193..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        224..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        414..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        769..787
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        799..822
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        879..907
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        969..992
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1238..1256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1277..1296
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1308..1328
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1354..1380
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1476..1499
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1558..1576
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1588..1606
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1618..1638
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1675..1703
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   TRANSMEM        1779..1802
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361132"
FT   DOMAIN          128..447
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          568..718
FT                   /note="Voltage-gated Na+ ion channel cytoplasmic"
FT                   /evidence="ECO:0000259|Pfam:PF11933"
FT   DOMAIN          768..998
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          1006..1231
FT                   /note="Sodium ion transport-associated"
FT                   /evidence="ECO:0000259|Pfam:PF06512"
FT   DOMAIN          1236..1508
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          1557..1812
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   REGION          28..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          477..537
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1141..1188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1981..2030
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..53
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        487..504
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        517..537
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1981..2004
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2005..2030
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2030 AA;  230103 MW;  1C6AC558DDF43748 CRC64;
     MAQLLIPPGP DSFRPFVPES LAAIERRIAE EEAQRPRVER RSDSDDENGP KPNSDVEAGK
     SLPFIYGDIP PGLVSTPLED IDPYYSSQKT FIVLNRGKAI FRFNATPALY ILSPFNPLRR
     IAIKVLVHSM FSILIMFTIL TNCAFMTLSN PPDWAKNVEY TFTGIYTFES LIKILARGFC
     VGKFTFLRDP WNWLDFSVIL MAYITEFVNL GNVSALRTFR VLRALKTISV IPGLKTIVGA
     LIQSVKKLSD VMILTVFCLS VFALIGLQLF MGNLRQKCVR IPLGSNTTLN NTHESNNTLV
     ENITLVENVT FMENITKNSF DWIEYINDER NYYYLPGRRD ALLCGNGSGA GSQVRLSRVC
     PEGFSCLKAG RNPDYGYTSF DTFSWAFLSL FRLMTQDYWE NLYQQTLRAA GKPYMIFFVL
     VIFLGSFYLV NLILAVVAMA YDEQNQATIE EAQQKEEEFQ AMLEQLKRQQ EEAQVAAAAA
     TESGEYSGRG RPTSESSSGT SKLSSKSAKE RRNRRKKRKQ REEEEERGCR DKFHKSESED
     SIKRSSFRFS IDANRLSYEK RCSSPNQSLL SIRGSIFSPR RNSRASLFSF RGRARDMGSE
     NDFADDEHST FEESDSRRGS LFLPRRLERR CSAVSQTSLG APRIMLPANG KMHCAVDCNG
     VVSLVGGTSV TTSPVGLLLP EGTTTDTELK KRRSGFHQPS MDYLNEPGGR QRAMSVASIL
     TNTMEELEES RQKCPPCWYR FANTGLIWDC CPAWLKIKEI VSMVVMDPFV DLAITICIVL
     NTLFMAMEHY PMTEEFDNVL SVGNLVFTGI FTAEMCFKII ALDPYYYFQE GWNIFDGIIV
     SLSLMELGLA NVEGLSVLRS FRLLRVFKLA KSWPTLNMLI KIIGNSVGAL GNLTLVLAII
     VFIFAVVGMQ MFGKNYKECV CKISEDCMLP RWHMHDFFHS FLIVFRVLCG EWIETMWDCM
     EVAGQTMCLI VFMMVMVIGN LVVLNLFLAL LLSSFSADNL AATDEDSEMN NLQIAVGRIQ
     RGIAFVKNAV RQFLQSLCFG RGGKGSGLAE ESKPLDELHS NGKGNCISNH TTVEITKDPS
     GVYMREGNGR PGGLVVGVSV GRDSTGKYPV EDCDYMSFIH NPSLTVTVPI AVGESDFENL
     NTEDFSSDSS DVEGSKEKLD VEPQPLSSSE GSTVDIRPPG DGVDSVELEP EESLDPEACF
     TEGCVRRFQC CQISEEGDKF KSWWTLRKTC FIIVEHNWFE SFIIFMILLS SGALAFEDIY
     IEQRRTIKTV LEYADKVFTY VFILEMLLKW VAYGFVKYFT NAWCWLDFLI VDVSLVSLVA
     NALGYSELSA IKSLRTLRAL RPLRALSRFE GMRVVVNALL GAIPSIMNVL LVCLIFWLIF
     SIMGVNLFAG KYYYCVNATT DEPFPSEVVN NKSDCLSLND SARWKNVKIN FDNVGAGYLA
     LLQVATFKGW MDIMYAAVDS RDLEEQPKYE VNLYMYLYFV IFIIFGSFFT LNLFIGVIID
     NFNQQKKKLG GQDIFMTEEQ KKYYNAMKKL GSKKPQKPIP RPTNAFQGCV FDFITKQAFD
     IVIMILICLN MVTMMVETDA QTKEMDHILY WINLVFIVLF TGECVLKMIS LRHYYFTIGW
     NIFDFVVVIL SIVGMFLSEV IEKYFVSPTL FRVIRLARIG RILRLIKGAK GIRTLLFALM
     MSLPALFNIG LLLFLVMFIY AIFGMSNFAY VKREAGIDDM FNFETFGNSM ICLFQITTSA
     GWDGLLAPIL NKRDPDCESQ LEHPGNSYKG NCGNPSVGIF FFVSYIIICF LIVVNMYIAV
     ILENFSVATE ESAEPLSEDD FEMFYEVWER FDPDATQFVA YSKLSDFADA LDPPLRIPKP
     NMIQLISMDL PMVSGERIHC LDILFAFTKR VLGEGGEMDM LRGQMEDRFM ASNPSKVSYE
     PITTTLRRKQ EEMSAIIIQR AFRRYMIRLA MKKASALYKE QLKEGMHDPD KDVMVISKFN
     ENSTSEKMDM TPSTASPPSY NSVTKSDKDK YEKENREREN KAKDLKDRKK
//
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