ID A0A3P8RCA1_ASTCA Unreviewed; 373 AA.
AC A0A3P8RCA1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Homeobox protein aristaless-like 4 {ECO:0000313|Ensembl:ENSACLP00000039645.1};
GN Name=ALX4 {ECO:0000313|Ensembl:ENSACLP00000039645.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000039645.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000039645.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000039645.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR AlphaFoldDB; A0A3P8RCA1; -.
DR STRING; 8154.ENSACLP00000039645; -.
DR Ensembl; ENSACLT00000040585.1; ENSACLP00000039645.1; ENSACLG00000026733.1.
DR GeneTree; ENSGT00940000159662; -.
DR OMA; AYDLNMD; -.
DR OrthoDB; 5400675at2759; -.
DR Proteomes; UP000265100; Chromosome 1.
DR Bgee; ENSACLG00000026733; Expressed in zone of skin.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR PANTHER; PTHR24329; HOMEOBOX PROTEIN ARISTALESS; 1.
DR PANTHER; PTHR24329:SF322; HOMEOBOX PROTEIN ARISTALESS-LIKE 4; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 177..237
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 353..366
FT /note="OAR"
FT /evidence="ECO:0000259|PROSITE:PS50803"
FT DNA_BIND 179..238
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 148..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 373 AA; 40899 MW; 167C38F615EFC4F7 CRC64;
MNTETCVSYS DMTSMDSYYS SSAAQGRDHQ TDHFRTFPAT DTKYSPAAFL PNKGQGYGEK
SRSPFQQECQ SLDAAAAGQG TFSKYHLFMQ RSSCKTPPEE DKLHQERGHN GALISCYGKD
SSGLADSDLA PDSDPPGMDT RYLAVKDQGV KAASDRTPGT DLASPLEKAD GGESNKGKKR
RNRTTFTSYQ LEELEKVFQK THYPDVYARE QLALRTDLTE ARVQVWFQNR RAKWRKRERF
GQMQQVRTHF STAYELPLLT RPENYAQIQN PSWIGGSSAA SPVPGCVVPC DTVTPCMTPH
PHSASGVSDF LGVPSPAGHM GQAHMGSLFG GSPGMAGGIN TYDLNMDPDR KSSSIAALRM
KAKEHSAAIS WAT
//
