ID   A0A3P8RDA2_ASTCA        Unreviewed;       793 AA.
AC   A0A3P8RDA2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Dimethylglycine dehydrogenase {ECO:0000313|Ensembl:ENSACLP00000039047.1};
GN   Name=DMGDH {ECO:0000313|Ensembl:ENSACLP00000039047.1};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000039047.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000039047.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000039047.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GcvT family.
CC       {ECO:0000256|ARBA:ARBA00008609}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3P8RDA2; -.
DR   Ensembl; ENSACLT00000039975.1; ENSACLP00000039047.1; ENSACLG00000026324.1.
DR   GeneTree; ENSGT00940000158176; -.
DR   OMA; NGWERPN; -.
DR   Proteomes; UP000265100; Chromosome 7.
DR   Bgee; ENSACLG00000026324; Expressed in liver and 7 other cell types or tissues.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR032503; FAO_M.
DR   InterPro; IPR028896; GCST/YgfZ/DmdA.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR   PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16350; FAO_M; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF103025; Folate-binding domain; 1.
PE   3: Inferred from homology;
FT   DOMAIN          3..342
FT                   /note="FAD dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF01266"
FT   DOMAIN          345..396
FT                   /note="FAD dependent oxidoreductase central"
FT                   /evidence="ECO:0000259|Pfam:PF16350"
FT   DOMAIN          407..672
FT                   /note="Aminomethyltransferase folate-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01571"
FT   DOMAIN          698..775
FT                   /note="Glycine cleavage T-protein C-terminal barrel"
FT                   /evidence="ECO:0000259|Pfam:PF08669"
SQ   SEQUENCE   793 AA;  88399 MW;  B5DD2428D36914EA CRC64;
     MKDVVLLEKT ELTAGSTWHA AGLTTYYHPG INLKKIHHDS IKLYETLEAE TGQAVGLHQP
     GSIRIASTPI RVDEMKYQMT RTHWHVTEQY LIGPEKIQEL FPLLNMDKVL AGLYTPGDGH
     IDPYSLTMAL AAGARMYGAQ IYNNAPVTSL EPTSDGKWDV QTSHGTIRAN RIVNTAGFWA
     REVGKMIGFE HPTIPVHHQY IVTATIPEVK ALKEELAVIR DLEGSYYLRQ ERDGLLFGPY
     EKMEKMVLQD SWVRDGVPPG FGKELFESDL DRIMEHVEKA MEMVPVLKKA DIINIVSGPI
     TYTPDLLPMV GPHCGVRNYW TAIGFGYGII HAGGIGKFLS EWITNGEPPY DLIECDPNRY
     GKWTDVPFIC AKARESYGFN NVVGYPKEER FAGRPTCRTS GVYELLKDKG SMGFHAGWEQ
     PHWFYKPGDD IGYKPSFQRT NWFGPVGREC KLVMEKVGVI DLTPFGKFIV KGKDSHKLLD
     RLFANTMPKV GMTNISHMLT PSGKVYAEVT ITQLAPGRFL LVTGSGSELH DLRWIETEVA
     QGGYDVDITN VTEDIGVLGI AGPNSRKVLQ KLTNEDMSEA GFKFLHCKSI QLAGKPVRAI
     RISYTGELGW ELYTDQKDLA AVYLAMMEAG KDEGIDNFGT YAMASLRLEK GFRGWGAEMN
     CDTNPLEAGL DYFIKLNKPA DFIGKAALQE IKAKGLNRKL SYIAVNTDDI DPEGNETVWY
     NGKVVGNTTS GAYSYSSQQS LAFAYLPLEL STLGQKVEVE LLGKKYPANV IQEPLIHTEP
     TRTRLQKKAQ SKA
//