ID   A0A3P8RDG1_ASTCA        Unreviewed;      1092 AA.
AC   A0A3P8RDG1;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000040075.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000040075.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000040075.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
CC       {ECO:0000256|ARBA:ARBA00005601}.
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DR   AlphaFoldDB; A0A3P8RDG1; -.
DR   Ensembl; ENSACLT00000041018.1; ENSACLP00000040075.1; ENSACLG00000026991.1.
DR   GeneTree; ENSGT00940000165903; -.
DR   Proteomes; UP000265100; Chromosome 7.
DR   Bgee; ENSACLG00000026991; Expressed in ovary and 4 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR049080; MOV-10-like_beta-barrel.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR   PANTHER; PTHR10887:SF322; RNA HELICASE MOV10L1; 1.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF21634; MOV-10_beta-barrel; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT   DOMAIN          533..599
FT                   /note="Helicase MOV-10-like beta-barrel"
FT                   /evidence="ECO:0000259|Pfam:PF21634"
FT   DOMAIN          761..830
FT                   /note="DNA2/NAM7 helicase helicase"
FT                   /evidence="ECO:0000259|Pfam:PF13086"
FT   DOMAIN          839..1048
FT                   /note="DNA2/NAM7 helicase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13087"
FT   REGION          334..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          673..698
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        345..371
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1092 AA;  121503 MW;  56A6C45C9AAF605E CRC64;
     MLTAVRCVLS KLVSPLWRTV EVEGDIFSHE SGREDIRHLR GQVITQLCLD YGMIDDAIYF
     TSGEVLGGVP LKEGDLVNCI AVRDGSEGGW KALRVEKSAD AWEDGGKTSL EADIMQLRPL
     VGMVTSFDGD GGYINQTTYF PCHSLWEGYE PMKGDWVQAK YFINPNQWTT KAHSVVPLRY
     CRLDQVRVTS IYGRSGVVDD SVFFNLDSLL LPAHYEPLVG DLVKLIMVES SQSLYSWRAL
     CMAPFSQSAN LSATPLREAE LKSILEDKGG LNVTDYGQFG ELMTGETREL VLWIQNKGSE
     THKFTHCDFA GWDSEEQFTL VSVKGLTSLR QKGQQLQENP VKSSEIQVKD GDKDNGDAQK
     EAVHSPGLRR QESELDILPG ERLPVVVACE AKSLGTCAEL LLLHFSSFTI GRRLEVTVRS
     ECEDVLQPSV PYAPTDSRPV AAKSSHVITV AAPKITPRLA NRRLPQFLPN YPVPQALRDC
     VEAQSDVLVV EPCLGEVLSP SNMQSRFSVL LWLEELNAER ELREFSISGA LLRKGAVYLH
     LEVPGLAEGR PNLYIGDRII LKKPQSDGVV MEYISYVTEI NDEDVSLRVN SDFQRSYLGE
     PLDVEFSYNR LTMRRCHSAL EQTKHFGEIL FPSRVTPRTP RWTGKWMDKL DDKTAPATEN
     GKVSGITIDM KSKGTQTKDC APTSKPIPTE GNFFNPDLNP PQKEAVKRIL AGECRPLPYV
     LFGPPGTGKT ITIIEAILQS IPEVLRVYSR AGEDIRQAAF HRIVVSTCSS AGMFHNIGLP
     VGHFTHLFLD EAGQATEPES LIPMSVVSER DGQIVLAGDP CQLGPLVKSK IASAFGFGVS
     LLERLMANPL YSRQDWGYNP KLVTKLVYNY RSHEALLTLP SKLFYQGELC CKGPRPIVDS
     LCQWKNLPKK SFPLLFHGVR GTEMREGNNP SWFNPVEAVQ VMLYCCQLAK KLYNPVHASD
     IGVIAPYKKQ CEKIRVLLGK VGLSDIKVGS VEEFQGQEFL VIILSTVRSS ESLQSDDLKS
     TLGFLANPKR FNVAITRPKA LLLIVGNPHI LIRDLCFRAL LEYCFINEAY LGCDPPSSLQ
     DVHTVAEEQR ST
//