ID A0A3P8RE75_ASTCA Unreviewed; 519 AA.
AC A0A3P8RE75;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Potassium two pore domain channel subfamily K member 5 {ECO:0000313|Ensembl:ENSACLP00000039874.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000039874.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000039874.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000039874.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR AlphaFoldDB; A0A3P8RE75; -.
DR STRING; 8154.ENSACLP00000039874; -.
DR Ensembl; ENSACLT00000040816.1; ENSACLP00000039874.1; ENSACLG00000026882.1.
DR GeneTree; ENSGT00940000156775; -.
DR OMA; WTYVEGL; -.
DR OrthoDB; 600333at2759; -.
DR Proteomes; UP000265100; Chromosome 19.
DR Bgee; ENSACLG00000026882; Expressed in ovary and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR003092; 2pore_dom_K_chnl_TASK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003:SF241; POTASSIUM CHANNEL SUBFAMILY K MEMBER 5; 1.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01095; TASKCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 80..137
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 170..246
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 471..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..519
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 58620 MW; CB8B977CA7BB3C1C CRC64;
MVDKGPLLTS AIIFYLSIGA AIFQVLEEPN WNQAVKQYNA QKDKILEKYP CLSGGDLDRI
LEVVSDAAGQ GVTITGNKTF NNWNWPNAVI FAATVITTIG YGNISPKTSA GRVFCIFYGL
FGVPLCLTWI SELGKFFGGR AKHLGLFLTK KGLSLRKSQF TCTAIFLLWG VLIHLVLPPL
VFMSQEGWSY IDGLYFSFVT LTTIGFGDMV AGVDPNKQYP PLYRYFVEVW IYLGLAWLSL
FFNWKVRMVI EAHKALKKRR KLRKLSLEEL RHYKESNKVS PTSPPTLNDV NIFSFLSKKK
EGYNDLIKQI GNKKDGSKTV CNSKEIGRSK SCTDAPMFNG HTILSLDRSP RQKRRYSFSD
CVTVAFSKSK NYLLGSDNGL LLKEDQVEGD LELNHDQMFE NQLDKDVNLE NGGERECVSV
GHRAWDSKEY HSLMFQNANI TFIDEENFLS NNSEELEDDD DDSKAKLSIT TCDENIETNS
KEEQSSESEG SVFTSDGSEH SHSYEKLVEE YAKEENTDS
//
