ID A0A3P8RGC0_ASTCA Unreviewed; 502 AA.
AC A0A3P8RGC0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Tubby-like protein {ECO:0000256|RuleBase:RU361125};
GN Name=TUB {ECO:0000313|Ensembl:ENSACLP00000040137.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000040137.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000040137.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000040137.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TUB family. {ECO:0000256|ARBA:ARBA00007129,
CC ECO:0000256|RuleBase:RU361125}.
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DR AlphaFoldDB; A0A3P8RGC0; -.
DR STRING; 8154.ENSACLP00000040137; -.
DR Ensembl; ENSACLT00000041080.1; ENSACLP00000040137.1; ENSACLG00000027049.1.
DR GeneTree; ENSGT00940000158372; -.
DR OMA; WSYDTLD; -.
DR Proteomes; UP000265100; Chromosome 1.
DR Bgee; ENSACLG00000027049; Expressed in brain and 2 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR025659; Tubby-like_C.
DR InterPro; IPR000007; Tubby_C.
DR InterPro; IPR018066; Tubby_C_CS.
DR InterPro; IPR005398; Tubby_N.
DR PANTHER; PTHR16517:SF20; TUBBY PROTEIN HOMOLOG; 1.
DR PANTHER; PTHR16517; TUBBY-RELATED; 1.
DR Pfam; PF01167; Tub; 1.
DR Pfam; PF16322; Tub_N; 1.
DR PRINTS; PR01573; SUPERTUBBY.
DR PRINTS; PR01574; TUBBYPROTEIN.
DR SUPFAM; SSF54518; Tubby C-terminal domain-like; 1.
DR PROSITE; PS01200; TUB_1; 1.
DR PROSITE; PS01201; TUB_2; 1.
PE 3: Inferred from homology;
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 35..236
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 254..497
FT /note="Tubby C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01167"
FT REGION 1..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 502 AA; 56423 MW; BF963F48F03A88C0 CRC64;
MEGVSSNRSM SYSRWSYDST LDDEGTNLRQ QKLDRQRALL EQKQKKKRQE PLMVQSNVDG
RSRTRRAKQS EEQAPLVESY LSSNSSTIYH VQEAEQEEVK VMSDPQPPRS AKKGKASASS
TPQTGSEKKE RKGKHKAIDG LASQQDDSQI QILTVGHPTS EEAEAEPVMS CTQSQSKQDL
RVTMLKKGIS SSMNFDEEED DDDEISSSSS QLNSNTRPGS ATSKKSSKEV ASAPTPPVSE
PAIDVDDLEE FSLRPAPQGV RVKCRITRDK KGMDRGMYPT YYLHLEREDG KKVFLLAGRK
RKKSKTSNYL ISIDPTDLSR GGESFIGKLR SNLMGTKFTV YDNGLNPMKS TTSLEASNLR
QELAAICYET NVLGFKGPRK MSVIIPGMNM DHERVSIRPR NDHESLLARW QNKNTESVIE
LHNKTPVWND DTQSYVLNFH GRVTQASVKN FQIIHDNDPD YIVMQFGRVA EDVFTMDYNY
PMCALQAFAI ALSSFDSKLA CE
//
