ID A0A3P8RGJ4_ASTCA Unreviewed; 472 AA.
AC A0A3P8RGJ4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=CARD domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000040066.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000040066.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000040066.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8RGJ4; -.
DR STRING; 8154.ENSACLP00000040066; -.
DR Ensembl; ENSACLT00000041009.1; ENSACLP00000040066.1; ENSACLG00000027004.1.
DR GeneTree; ENSGT01100000266301; -.
DR OMA; SCYLFRN; -.
DR Proteomes; UP000265100; Chromosome 10.
DR Bgee; ENSACLG00000027004; Expressed in anal fin and 5 other cell types or tissues.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR004021; HIN200/IF120x.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR46985:SF2; APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD; 1.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF02760; HIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF159141; HIN-2000 domain-like; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50834; HIN_200; 1.
PE 4: Predicted;
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198}.
FT DOMAIN 112..263
FT /note="HIN-200"
FT /evidence="ECO:0000259|PROSITE:PS50834"
FT DOMAIN 380..470
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 472 AA; 53845 MW; F19F209B3E25EDA1 CRC64;
MDQMSREDDS LQDELLSKQK KESVSSSSRK RKVDKTESAG SVMPKKKKTE NKVSSLKSTR
ATKTTKAALS EKPKKKENKQ KAKKKDELRM RKFIHDVKTS GDLGNKVIAG KVLAKSGLRT
YETKKKEKKF FFYLGVATET GSIKVMVYGR ERYQRFQEKS CYLFRNVIMD KNVMKVTKKS
VISKTAAIDV PENLEMEAQM FVYSQTQVCS IEQAIGSAEK TSVSVKGKVR KIDTLKKKQG
SANRKEFQLE DSTGSIWITL WGEDIKQLRG KSPGDSVRVV NVETNHYNDV SLNSTDFTRI
SKERVVSKQK NKQESKKKES VSSSSRKRKV DKTESAGSVM PKKKKTENKV SSLKSTRATK
TTKAALSEKP KKKENKQKAK KKGQKHFVDE HRSKLIQRVS NIAPILDDLL QKDFIDEEVY
ADIRAHKTPQ EKMRNLLSHI VKDGDTSKEA FYQVLRKHQK MLIENLIQNS TK
//
