ID A0A3P8RHH9_ASTCA Unreviewed; 1200 AA.
AC A0A3P8RHH9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=DENN domain containing 5A {ECO:0000313|Ensembl:ENSACLP00000040401.1};
GN Name=DENND5A {ECO:0000313|Ensembl:ENSACLP00000040401.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000040401.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000040401.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000040401.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC {ECO:0000256|ARBA:ARBA00006664}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR AlphaFoldDB; A0A3P8RHH9; -.
DR Ensembl; ENSACLT00000041353.1; ENSACLP00000040401.1; ENSACLG00000027199.1.
DR GeneTree; ENSGT00940000153678; -.
DR Proteomes; UP000265100; Chromosome 1.
DR Bgee; ENSACLG00000027199; Expressed in ovary and 8 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR CDD; cd01757; PLAT_RAB6IP1; 1.
DR CDD; cd17690; RUN1_DENND5A; 1.
DR Gene3D; 1.20.58.900; -; 3.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR047277; PLAT_RAB6IP1.
DR InterPro; IPR047294; RUN1_DENND5A.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR46070:SF2; DENN DOMAIN-CONTAINING PROTEIN 5A; 1.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF02759; RUN; 2.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00593; RUN; 2.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF140741; RUN domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50826; RUN; 2.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..509
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 698..863
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 867..975
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 1047..1195
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 69..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1200 AA; 137618 MW; 4E9047DAA9364664 CRC64;
MLCMPKGLAF RTQMDSREPQ FHSFIITRED GSRTYGFALT FFEEVTSKQI CSAMQTLYHM
HNAEQYDILH TPTSPQGPED QRRQHTPSRP MLHAAPAISR LQRFNSYDIS RDTLYVSKCI
CLITPMAFAQ ACSKVLQQLH QAVSSPQPPP LPLESYIYNI LYEVPLPPSG RSLKFSGVYG
PVVCQRPSTS ELPLFDFAIS EMFNLLGVEN VLQLFTCALL EMQILLYSQH YQRLMTVAES
ITALMFPFQW QHVYVPILPA SLLHFLDAPV PYLMGLHSNG QDDRTKLELP QEANLCFVDI
DNHFIELPEE LPQFPNKLEF IQEISEVLMS FGVSPEGNIY SSDSQAKYRG FRAADMVSDK
RNGNLASPLN SYLLRENETI ARLQALVKRT GVSLDKLEVR EDASSNKDGR VQCDEEELKM
HQLNIQVREV FANRFTQMFA DYEVFVIQPS HDKESWFTNR DQMQNFDKAS FLSDQPEPYL
PFLSRFLETQ MFASFIDSKI LCHDDEEKEH TLRVFDARVD KIRMLNVRTP TLRTSMYQKC
TNIEEAEKAI EMRVSKIDHT ALHPHLLDMK IGQGRYEQGF FPRLQSDVLS TGPTSNKWAK
RSAPAQWRRR DRQKQHAEHL YLDNDQREKY IQEARNLGTT IRQPKLSNLS PSVIAQTNWK
FVEGLLKECR NKTKRMLVEK MGREAVELGH GEVSITGVEE NTLIASLCDL LERIWSHGLQ
VKQGKSALWS HLLHYQDSKE KKNATPGSLG PPGFIHDTER RKSDGGGSVM PPLKISLIQD
MRHIQNISEI KTDVGKARAW VRLSMEKKLL SRHLKQLLSD HELTKKLYKR YAFLRCDDEK
EQFLYHLLSF NAVDYFCFTN VFTTIMIPYH VVVVPSKKLG GSMFTANPWV CVSGELAETG
VLQVPRNTLE ITFECQNLGK LTTVQMGHDN TGLYAKWLVE CVVVRNEITG HTYKFPCGRW
LGKGVDDGSL ERILVGELMT PSSENDERMC RTPPMQQSPG MIRRFVTISP NSKPKLNTGQ
IQEGVGEAIN GIVKHFHKPE KERGSLTLLL CGEYGLVWAL EQVFQHGFKS PRLFKNVFIW
DFLEKAQVYF ESAEQREVTP DENWQTRVRH FCRFMRAINN APRNIGKDGK FQMLVCLGAR
DHLLHHWIAL LADCPITSQM YEDTALIKDR SLVNALIRVL QTLQEFNITL EASLVKGVGI
//
