ID   A0A3P8RHK6_ASTCA        Unreviewed;       772 AA.
AC   A0A3P8RHK6;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=F-BAR domain only protein 2 {ECO:0000256|ARBA:ARBA00018998};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000040582.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000040582.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000040582.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane, clathrin-coated pit
CC       {ECO:0000256|ARBA:ARBA00004283}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004283}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004283}.
CC   -!- SIMILARITY: Belongs to the FCHO family.
CC       {ECO:0000256|ARBA:ARBA00011064}.
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DR   AlphaFoldDB; A0A3P8RHK6; -.
DR   Ensembl; ENSACLT00000041538.1; ENSACLP00000040582.1; ENSACLG00000027259.1.
DR   GeneTree; ENSGT00940000157105; -.
DR   Proteomes; UP000265100; Chromosome 7.
DR   Bgee; ENSACLG00000027259; Expressed in liver and 8 other cell types or tissues.
DR   GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR   CDD; cd07673; F-BAR_FCHO2; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR036168; AP2_Mu_C_sf.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR030122; FCHo2_F-BAR.
DR   InterPro; IPR028565; MHD.
DR   InterPro; IPR018808; Muniscin_C.
DR   PANTHER; PTHR23065:SF8; F-BAR DOMAIN ONLY PROTEIN 2; 1.
DR   PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF10291; muHD; 1.
DR   SMART; SM00055; FCH; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS51072; MHD; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          1..246
FT                   /note="F-BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51741"
FT   DOMAIN          504..772
FT                   /note="MHD"
FT                   /evidence="ECO:0000259|PROSITE:PS51072"
FT   REGION          404..496
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          83..152
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        419..434
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        463..496
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   772 AA;  85572 MW;  2F640B9B94637D40 CRC64;
     MWKKKTKGEK NNGFDVLYHN MKHGQISTKE LTDFIRERST IEEAYARSMT KLAKSAGNFS
     QLGTFAPMWD VFKGSTEKLA SCHMELVRKL QELIKEVQKY VEEQSKAHKK TKEEVASTLE
     AVQNIQSIFQ ALQKSKENYN AKIVEQERLR KEGATQRDVD KAGVKAKKAT ETYKSYVEKY
     ATAKSEFEQK MTETAQKFQD IEENHILHMK EIIQSYSLYV DETHIQIGEV HHEFVRNIEN
     TSVESLIQKL AESKGTGKER PGKPPGSCIK ENRILLVFLQ NVPQVDEEGF CIRPEVNEND
     ILFCLSQQNS FYSSSDSEDE DEPRKFHVQI KPVQPNNGVH QNQANIDELK ASIGNIILSP
     STSVRKVTSV YLTFSFSRNY GRLTNNDLLS LDPLSPAQAI RSSSAVSSSA VPNRPTTPLA
     PGALVPPPRP SSRPKLPAGK LTGINEIVRP FSPPKASSPT PTAPLARAES SSSLSSNASL
     SAGNTPTVGT SRGPSPVTLA SQDALPIAVA FTESVNAYFK GADPTKCIVK ITGDMTLSFP
     MGIIKVFTTN PSPAVLTFKL KNTSRLEQIL PNQQLLYSDP SQSDSDSKDF WFNMQALTSY
     LRKASEQSPS ASYYNVDILK YQVMSDGIHS TPLNLAVYWK CTASTTDLRI DYRYNPESMD
     SPSPLTNVQI LVPVDGGVTN MQSLPNSIWN SEQSKCLWRL TDISEKSEND GAGSLRAKFE
     LSNGPSHPST LAVQFMNEGS TLSGVDMELQ GAGYRLSLSK KRFATGRYMA DC
//