ID A0A3P8RHU6_ASTCA Unreviewed; 1639 AA.
AC A0A3P8RHU6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Laminin subunit gamma-3-like {ECO:0000313|Ensembl:ENSACLP00000041174.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000041174.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000041174.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000041174.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR STRING; 8154.ENSACLP00000041174; -.
DR Ensembl; ENSACLT00000042143.1; ENSACLP00000041174.1; ENSACLG00000027721.1.
DR GeneTree; ENSGT00940000166104; -.
DR OMA; GAQKTCT; -.
DR OrthoDB; 90222at2759; -.
DR Proteomes; UP000265100; Chromosome 7.
DR Bgee; ENSACLG00000027721; Expressed in ovary.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
DR CDD; cd00055; EGF_Lam; 9.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF240; LAMININ SUBUNIT GAMMA-3; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 11.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00180; EGF_Lam; 11.
DR SMART; SM00281; LamB; 1.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 10.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01248; EGF_LAM_1; 4.
DR PROSITE; PS50027; EGF_LAM_2; 8.
DR PROSITE; PS51115; LAMININ_IVA; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Secreted {ECO:0000256|ARBA:ARBA00022869}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1639
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018084053"
FT DOMAIN 39..275
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 332..387
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 388..434
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 435..484
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 511..683
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 718..765
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 821..876
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 877..927
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 928..975
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 976..1023
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT COILED 1028..1055
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1241..1268
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1588..1622
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 360..369
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 388..400
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 408..417
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 455..464
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 735..744
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 845..854
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 900..909
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 928..940
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 930..947
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 949..958
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 976..988
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 996..1005
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1639 AA; 181069 MW; 19C782EF11D5D8F4 CRC64;
MDTSFTVRPL VLALLLSLHL HLHLFVWAAM DSCYDEEGVP SSCMPKFENI AFSRTVVASN
VCGSPPEDYC MQTGSTRSCH ICDASDPYLS HNTSLLTDFH RNEEPTWWQS QSMYFRIQYP
NSVNLTLHLG KSFEITYIRL KFYTSRPESF AIYKRTENDG PWLPYQYYSA SCRKTYERDA
KGYIRPGDDE RTALCTDEFS DISPLTGGNV AFSTLEGRPS AYNFDQSLVL QEWVTATDLL
ISLDRLNTFG DEFFKDAKVL RSYFYAISDF SVGGRCKCNG HASECIEREH GNLVCACQHH
TEGADCQRCH PFYQDRPWAR ATGDSANECL KCNCSGRSDQ CVFDMEQYRS TGSGGRCVSC
RDNTDGPHCE RCRNGYYRKS TEDPCLPCNC NVNGSVSLQC DVEGRCACRE GVTGEKCNTC
QAGFHSIGPG GCRPCECDLS GSVGDCSALD GRCYCKQNVE GQNCNRCKPG FFNLQQINPA
GCQPCFCYGH SLACSSSNHY AAVNITSDFV EDQEGWLGEF SGGLDYPLLW KEGEVYLLPL
TEEDTGFYKA PVKFLGHKVY SYGQLLFITF ASETPELLPD HIALVLEGSG ITLSADLSSQ
PVLGCHPGLT PRHSFTIRLD ENEKRFKPAL SAFDFQLLLY NLTALKISNA GGHNYTSQLA
GVTMTSAVVS ADPAFPPALW VESCSCPPGF AGQFCEQCAP GFTREEPARG PLSTCVPCNC
HQHGTCHPET GVCECSDFTT GTTCERCLDG YYGNSLIGTP GDCQPCPCPG QTSCVQIAET
GQVVCTNCPA GQTGMRCQRC EDGYYGDPLG LSGAAQPCAR CNCNGNVDFN AVGICDHVTG
RCLKCLGHTE GDHCERCQQG FYGNALDQTV GQKCKSCSCS SAGTSGHVNE CHPQTGNCHC
LSHVTGRDCS YCEVGFFNLQ PGIGCEICKC NPIGSSSLAC HPITGQCVCR TGVEGRLCDT
CRLGFFGFSS RGCRACNCDP MGSVSMQCRS NGTCHCRQGF VGYKCDKCEL NYFHNRATHQ
CEECPVCYGL VKKQAEKLRT RLQDLEKLLA HFDCRGRFGK RHHLLKYHMA RLYEHEHQRE
DTLPNALEDF LAFQEAREAL IKQFSLLEAS TGTLLAQLHG ITSSLNCSIS MTEEEGKERR
KDESSGAVCQ TFTDTLHMIR VSQKQLKQAT QDLDNMLIPF EAVSRPNKWN IMVNDSQVLM
KSHRETADHI EAIADRAVRA SKQTYSSLMD LLQDNSTEEY IRNLTEQITQ MQQQKENLTV
QVNDTVAEQL ALEEEAAGLK LALGNITSFL HQLALTDASP YPEADHTQFN QTKHLTNFTT
EWGETLVKQT KELDQQVQTQ DGLIAKVREV VEPLLQTVNN SMESVNNVSK LQTQAHGAKV
VTLSSVVTGK EVESEAISLH RQLERMVTQW PRQQAQTKAA IKKARPLEEK ILPDVRKKVA
ETEKMLKPAL EHSNISSSTA KDAEQKAHAV VKESKAILTQ AKHTRTASAH LSSNIDSALE
QLSVQELLTD RANTQITSEP GVSLASVKED MEAAKLQLEA YSVTLTELIS KIDGDVPLER
FHRILNETAH RLSMLRGSVE SPTLGSKIQK LQSAAKEQQS RLSLIEQDIQ EITEERDSLR
DIALNLPQSC PEATGAGKG
//
