ID A0A3P8RJ92_AMPPE Unreviewed; 1657 AA.
AC A0A3P8RJ92;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=MAP kinase-activating death domain protein {ECO:0000256|ARBA:ARBA00017868};
GN Name=MADD {ECO:0000313|Ensembl:ENSAPEP00000000137.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000000137.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000000137.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000000137.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the MADD family.
CC {ECO:0000256|ARBA:ARBA00005978}.
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DR Ensembl; ENSAPET00000000139.1; ENSAPEP00000000137.1; ENSAPEG00000000100.1.
DR GeneTree; ENSGT00940000156718; -.
DR Proteomes; UP000265080; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR039980; MADD.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR13008:SF7; MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN; 1.
DR PANTHER; PTHR13008; MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 13..575
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 104..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 776..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1617..1657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..934
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1228..1252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1627..1644
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1657 AA; 183007 MW; 30EE35E445CC3B58 CRC64;
MEKKKTCPRL LDYLVVVGAR QPSSDSVAQT PQLLRRYPLE DHHDFPLPPD VVFFCQPEGC
LSIRQRRVSL RDDSSFVFTL TDKDSGITRY GICVNFYRSF QRGHHRSRGD KSRDAESAAP
PVETATEASE DGGPTSTLAP PNNAESAPPP SSGEEGEKPA AEQNAGKSPQ HRRSTAKMAA
RNRNSTLTSL CILSHYPFFS TFRECLYILK RLVDCCSQRL TQRAGLPRAT QRDTMWRVFT
GATSVEEKGS QLLADLREIE SWVYRLLRSP VPLAGQRRVD VEVLPHELKR ALTFALPDNS
RFAMVDFPLH LPLELLGVDA CLQVLSCVLL EHKVILQSRD YNALSMSVMA FVAMIYPLEY
MFPVIPLLPT CMASAEQLLL APTPYIIGVP ASFFLYKSDF KMPDDLWLVD LDSSKVIAPT
NAEILPPLPE PEAGELKKHL KQALASMSLN TQPILNLEKF QEGQEMPLLP PGRDKASPSS
TEFNPLIYGN DVDSVDVATR VAMVRFFNSP NVLQGFQMHT RTLRLFPRPV VAFQSTSFLA
SRPRRSSFAD KLSHTQAVEF YGEWALNPTN LAFQRIHNNV FDPSLIGDKP KWYAHQLQPV
LYRVYDGSSQ LVEAMAGPLE DEGNESDPTD SGSDSEAYDD SSSSYSSLGD LVSEMIQGDI
QGDTPSLDPL THAALGDASE VEFQDFQDFR EGHGAEGPPS GDGPADPSDG QPLRSSSSTT
ASSSPSTIIQ GVNHEQGEVP EIEASASAAL QNPVPGLGSQ PFLRPAADAG LVDPANKKQE
YDNPYFEPQY GFPSEDDPDA EEQVESYTPR FNQNLNGNKA QRPLRPSSLR LPGESDGEGD
SHNSSPNSTI SNSSNDGFGG LMSFASNLYK NHGTSFSLSN LALPNKAARE KSTPFPSLKG
ARAPRALVDQ KSSVIKHSPT VKRESPSPQG RVNNTSENQQ FLKEVVQSVL DGQGVGWLNM
KKVRRLLENE QLRVFVLSKL NRAVQSEEDA RQEIIRDVEV SRKVYKGMLD ILKCTVSSLE
HSYTNAGLGG MASVFSLLEI ARTHYQTKDP EKRKRSPTDS AGSPGSKESP SGRMETSRPQ
GLLNIPHLQL PHHTTGKGAR HFDTRSLNEE NFIASIELWS KHQDKQKAME KPQRSEGAKQ
QRPQVTDAEE KKSQISADSG LSVASGSQKS DTESVTSSEP PILTRSTSQD SEASTVISNS
SGETLGADSD LSSTGGDGLG GRTAPHLAQS RGTLSDSEIE TNPATSAVFG KTHTLKSGAK
DQVPAVAKGP PAQPMEDISM RIYLCEGLLG RDKSSVWDQL EDAAMETFSL SKERSTLWDQ
VQFWEDAFLD AVMLEREGMG MDQGPQEMIE RYLSLGEHDR KRLEDDEDRL LATLLHNMIA
YMLMLKVNKN DIRKKVRRLM GKSHIGLTYS QEINEILDKL ANMNGRELSI RPSGSRHIKK
QTFVVHAGTD TTGDIFFMEV CDDCIVLRSN IGTVYERWWY EKLINMTYCP KTKVLCLWRR
NGQETQLNKF YTKKCRELYY CVKDSMERAA ARQQSIKPGP ELGGEFPVQD MKTGEGGLLQ
VTLEGINLKF MHSQVRGRSD GPTAAAAHLT GHGDPNHHLP VLLPPLCSSV GFISSRLPLS
PPRTPKHSSK TPKHGSKTPK HGSKTPKHAT QNPKTRH
//
