ID   A0A3P8RK25_ASTCA        Unreviewed;       264 AA.
AC   A0A3P8RK25;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Carboxypeptidase B2 (plasma) {ECO:0000313|Ensembl:ENSACLP00000041447.1};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000041447.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000041447.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000041447.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M14 family.
CC       {ECO:0000256|ARBA:ARBA00005988}.
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DR   AlphaFoldDB; A0A3P8RK25; -.
DR   Ensembl; ENSACLT00000042425.1; ENSACLP00000041447.1; ENSACLG00000027901.1.
DR   GeneTree; ENSGT00940000159160; -.
DR   Proteomes; UP000265100; Chromosome 23.
DR   Bgee; ENSACLG00000027901; Expressed in liver.
DR   GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR000834; Peptidase_M14.
DR   PANTHER; PTHR11705:SF17; CARBOXYPEPTIDASE B2; 1.
DR   PANTHER; PTHR11705; PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B; 1.
DR   Pfam; PF00246; Peptidase_M14; 1.
DR   PRINTS; PR00765; CRBOXYPTASEA.
DR   SMART; SM00631; Zn_pept; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR   PROSITE; PS00133; CARBOXYPEPT_ZN_2; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022645};
KW   Protease {ECO:0000256|ARBA:ARBA00022645}.
FT   DOMAIN          145..155
FT                   /note="Peptidase M14 carboxypeptidase A"
FT                   /evidence="ECO:0000259|PROSITE:PS00133"
SQ   SEQUENCE   264 AA;  30589 MW;  0C5FCBD952AAE88C CRC64;
     MYDHTCITLH SMWIDCGIHA REWISPAFCL WFVHHSLSFY QQNSEITRIL DSMDVYVLPV
     MNPDGYKYTW TRRWWRKNRS ISKSGFCVGV DLNRNFDVDW VKGSSQNPCE EINCGPFPES
     EPEAQAVANF LRRHKDTVQL YITIHSYSQM FIFPYSYTFD QAENHNDLMV QEAAQRIKRY
     YRNTYTYGPG AATLYPCSGG SDDWAYKLGI KYSFTFELQD RGEYGFLLPP SHISGACNEA
     LLAVKTIAVK VLEKTQAPAN HHTI
//