ID A0A3P8RK34_ASTCA Unreviewed; 1600 AA.
AC A0A3P8RK34;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Calmodulin-regulated spectrin-associated protein 1-B-like {ECO:0000313|Ensembl:ENSACLP00000041457.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000041457.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000041457.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000041457.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
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DR STRING; 8154.ENSACLP00000041457; -.
DR Ensembl; ENSACLT00000042435.1; ENSACLP00000041457.1; ENSACLG00000027907.1.
DR GeneTree; ENSGT00950000182975; -.
DR OMA; FIAEVFW; -.
DR OrthoDB; 2918432at2759; -.
DR Proteomes; UP000265100; Chromosome 7.
DR Bgee; ENSACLG00000027907; Expressed in camera-type eye and 2 other cell types or tissues.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.10.20.360; CKK domain; 1.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR038209; CKK_dom_sf.
DR InterPro; IPR014797; CKK_domain.
DR InterPro; IPR011033; PRC_barrel-like_sf.
DR PANTHER; PTHR21595:SF3; CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR21595; UNCHARACTERIZED; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF08683; CAMSAP_CKK; 1.
DR SMART; SM01051; CAMSAP_CKK; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50346; PRC-barrel domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51508; CKK; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|PROSITE-
KW ProRule:PRU00841}.
FT DOMAIN 249..364
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1465..1599
FT /note="CKK"
FT /evidence="ECO:0000259|PROSITE:PS51508"
FT REGION 411..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 837..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1051..1217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1293..1315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1337..1375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1014..1041
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 411..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..644
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..747
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..797
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..993
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 995..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1083
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1149..1171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1180..1195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1600 AA; 177658 MW; 063CB9C9FABBFE8D CRC64;
MDVEVSAGRD STWRRAAAAT ANDDGAGGGG GGGVMEAQVV PLELYDCARA KIDANLRWLF
AKAYGTDHVP ADLRDPFYTD QYEQEHIKPP IIRMLQSGDL YCRVCGLILH AEQASSLQNH
QSVIQALSRK GIYVLETDNA PVSDLDLSAS PIKMSAHIHL IDSLMMAYTV EMISIEKVVS
SVKRFSTFSA SKELPYDLED VMLFWINKVN IKLREITEKE CKMKQHLLDS PSHQKPDILH
ALAHCLLEPV EFSRVVRYRR DHLSGRTLQH FPLLDDLLKD MCDGTALLAV IHFYCPELVR
LEDICLKEVP SISESVYNIQ LLMEFSNEYL NKCFYLKPED LLYSPPVLKN NVMVFIAELF
WWFEIVKPDF VQPRDLQDIR DVRLLLQPKT SRSYVPISNI TKRSFLTSSH SADTLATPTS
PDLSTKSSST SPSVLPLRQR QQKVVEETTP DIRHRPNSLI GPDAQHQGSK MAWPERRTRP
LSQPASYALH FAPEDDADSI SLARSISKDS LASNIMSITP KHMLGAGLSQ HRLSGQSLLS
HMRIEDEEEE IEEEELVAVI HPSVFSRHRI GSNMEQDELE MQSAAPASKV CNASRPSCFD
AGPFTLDCRG DSYYLEPLLP AIPKMAKEKS ISLNKQEESG ESRCRGTGNA RNATAGVPRT
SQRKSPSSCT PTQVVESVPS SLRQLIEDSA VDSQPGKKQS EGFFLHLSDE PDQHSSFSID
CMPEAGPDSD SDIADLEEDE EEEDQMELMK EEVKGGRGKC PEEDDTAEFG EFGEGESAKL
REDMKVSERE DKEDCSGRSS PCPSTISWAS SCSASGSASV KMTSFAERKL LKLGLRDGYS
STSSSQKTTP DGSDVTPCPP WQLRNDSTSG LLGKEPSTVM GKNTALSSPV VPSELLQLHM
QLEEQRRAIE YQKKKMETVS ARQRLKLGKA AFLNIVKKGG GRSDTLPLPL KHSKESLALT
SADRSKSKSQ TSRDDSCLDA LKVRTKGGQR EEGPMNTDNR LNALSQDNGA EPDINECSRS
IELLNEAIST IQQQMMQLSL QQNLLMKQSV ASPPDLVPSG PSTPPDTNPT QQTPSTSDSR
SYAVHFVDIS AGSAAPTRRP PKLSSSQRSK APELKQSKEN SKSVKKSNIQ LPECAEGEEV
ESTAESSRTE RSLQRNTTFR VQDSTGEGTG RLSDKLKSPD PPVISSTTQF PSQDGEQEKD
AAVRSRMEVA SGEESTRVKG QLIEVDLSEL KDQLEDGTVD APDCVAEGEQ KNVLGFFFKD
DEKAEDEMAK RRAAFLLKQQ RKAEEARLRK LQQEAESELK RDEARRKAEE DRIRKEEEKA
RRELIKQEYL RRKQQALMEE QGLVKPRPRT KARRNRPKSL HREESSSLSK GSATRNSLKV
SMLIKAQDSA AGCRGADLSC SHRGSTLSLA TDADSVISGG AESNRAGSVC SMESFPLSRA
SSRNMERDWE NVSIASSITS NEYTGPKLFK EPSSKSNKPI IINAIAHCCL AGKVNEVQKS
VVLEELEKCE SNHLIILFRD GGCQFRAIYS YSPDTEEIIK FSGTGPRTIN RKMIDKLYKY
SSDRKQFTVI PAKTVSVSVD ALTIHNHLWQ VKRPGSARRK
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