ID A0A3P8RKT1_AMPPE Unreviewed; 1676 AA.
AC A0A3P8RKT1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=MAP kinase-activating death domain protein {ECO:0000256|ARBA:ARBA00017868};
GN Name=MADD {ECO:0000313|Ensembl:ENSAPEP00000000135.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000000135.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000000135.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000000135.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the MADD family.
CC {ECO:0000256|ARBA:ARBA00005978}.
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DR STRING; 161767.ENSAPEP00000000135; -.
DR Ensembl; ENSAPET00000000137.1; ENSAPEP00000000135.1; ENSAPEG00000000100.1.
DR GeneTree; ENSGT00940000156718; -.
DR OMA; KILCLWR; -.
DR Proteomes; UP000265080; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR039980; MADD.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR13008:SF7; MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN; 1.
DR PANTHER; PTHR13008; MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 13..594
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 104..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1636..1676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..873
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..953
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1097
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1247..1271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1646..1663
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1676 AA; 185196 MW; 746BAEA59C360E90 CRC64;
MEKKKTCPRL LDYLVVVGAR QPSSDSVAQT PQLLRRYPLE DHHDFPLPPD VVFFCQPEGC
LSIRQRRVSL RDDSSFVFTL TDKDSGITRY GICVNFYRSF QRGHHRSRGD KSRDAESAAP
PVETATEASE DGGPTSTLAP PNNAESAPPP SSGEEGEKPA AEQNAGKSPQ HRRSTAKMAA
RNRNSTLTSL CILSHYPFFS TFRECLYILK RLVDCCSQRL TQRAGLPRAT QRDTMWRVFT
GATSVEEKGS QLLADLREIE SWVYRLLRSP VPLAGQRRVD VEVLPHELKR ALTFALPDNS
RFAMVDFPLH LPLELLGVDA CLQVLSCVLL EHKVILQSRD YNALSMSVMA FVAMIYPLEY
MFPVIPLLPT CMASAEQLLL APTPYIIGVP ASFFLYKSDF KMPDDLWLVD LDSSKVIAPT
NAEILPPLPE PEAGELKKHL KQCLVRLTVI TQKQIFSSEN KALASMSLNT QPILNLEKFQ
EGQEMPLLPP GRDKASPSST EFNPLIYGND VDSVDVATRV AMVRFFNSPN VLQGFQMHTR
TLRLFPRPVV AFQSTSFLAS RPRRSSFADK LSHTQAVEFY GEWALNPTNL AFQRIHNNVF
DPSLIGDKPK WYAHQLQPVL YRVYDGSSQL VEAMAGPLED EGNESDPTDS GSDSEAYDDS
SSSYSSLGDL VSEMIQGDIQ GDTPSLDPLT HAALGDASEV EFQDFQDFRE GHGAEGPPSG
DGPADPSDGQ PLRSSSSTTA SSSPSTIIQG VNHEQGEVPE IEASASAALQ NPVPGLGSQP
FLRPAADAGL VDPANKKQEY DNPYFEPQYG FPSEDDPDAE EQVESYTPRF NQNLNGNKAQ
RPLRPSSLRL PGESDGEGDS HNSSPNSTIS NSSNDGFGGL MSFASNLYKN HGTSFSLSNL
ALPNKAAREK STPFPSLKGA RAPRALVDQK SSVIKHSPTV KRESPSPQGR VNNTSENQQF
LKEVVQSVLD GQGVGWLNMK KVRRLLENEQ LRVFVLSKLN RAVQSEEDAR QEIIRDVEVS
RKVYKGMLDI LKCTVSSLEH SYTNAGLGGM ASVFSLLEIA RTHYQTKDPE KRKRSPTDSA
GSPGSKESPS GRMETSRPQG LLNIPHLQLP HHTTGKGARH FDTRSLNEEN FIASIELWSK
HQDKQKAMEK PQRSEGAKQQ RPQVTDAEEK KSQISADSGL SVASGSQKSD TESVTSSEPP
ILTRSTSQDS EASTVISNSS GETLGADSDL SSTGGDGLGG RTAPHLAQSR GTLSDSEIET
NPATSAVFGK THTLKSGAKD QVPAVAKGPP AQPMEDISMR IYLCEGLLGR DKSSVWDQLE
DAAMETFSLS KERSTLWDQV QFWEDAFLDA VMLEREGMGM DQGPQEMIER YLSLGEHDRK
RLEDDEDRLL ATLLHNMIAY MLMLKVNKND IRKKVRRLMG KSHIGLTYSQ EINEILDKLA
NMNGRELSIR PSGSRHIKKQ TFVVHAGTDT TGDIFFMEVC DDCIVLRSNI GTVYERWWYE
KLINMTYCPK TKVLCLWRRN GQETQLNKFY TKKCRELYYC VKDSMERAAA RQQSIKPGPE
LGGEFPVQDM KTGEGGLLQV TLEGINLKFM HSQVRGRSDG PTAAAAHLTG HGDPNHHLPV
LLPPLCSSVG FISSRLPLSP PRTPKHSSKT PKHGSKTPKH GSKTPKHATQ NPKTRH
//
