ID   A0A3P8RL75_AMPPE        Unreviewed;       223 AA.
AC   A0A3P8RL75;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Tetraspanin {ECO:0000256|RuleBase:RU361218};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000000089.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000000089.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000000089.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU361218}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361218}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000256|ARBA:ARBA00006840, ECO:0000256|RuleBase:RU361218}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU361218}.
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DR   AlphaFoldDB; A0A3P8RL75; -.
DR   STRING; 161767.ENSAPEP00000000089; -.
DR   Ensembl; ENSAPET00000000091.1; ENSAPEP00000000089.1; ENSAPEG00000000063.1.
DR   GeneTree; ENSGT00940000157667; -.
DR   OMA; CYSAMVD; -.
DR   Proteomes; UP000265080; Chromosome 1.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd03156; uroplakin_I_like_LEL; 1.
DR   Gene3D; 1.10.1450.10; Tetraspanin; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR000301; Tetraspanin_animals.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR19282; TETRASPANIN; 1.
DR   PANTHER; PTHR19282:SF249; TETRASPANIN-18; 1.
DR   Pfam; PF00335; Tetraspanin; 2.
DR   PIRSF; PIRSF002419; Tetraspanin; 2.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361218};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Transmembrane {ECO:0000256|RuleBase:RU361218};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM        12..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361218"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361218"
FT   TRANSMEM        193..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361218"
SQ   SEQUENCE   223 AA;  24902 MW;  76D57786D1F4DD57 CRC64;
     MEGDCLSCMK YLMFIFNFFI FLGGSFLLGV GVWVLVDPMG FREIVAVNPL LFTGVYVILA
     MGALLFLLGF LGCCGAIREN KCLLLFVSDH VMVLTRQYFT RDLKRHYQGR NNTDVFSSTW
     NAIMTTFDCC GVSGPEDFEE SLFRLLSPSK MVPEACCQRN GFLGDGGMEQ CVSGHVFSLQ
     GCYSAMVDYF ETYIYTAGAL AIVVLTIELF AMVFAMCLFR GIQ
//