ID   A0A3P8RLC3_AMPPE        Unreviewed;       797 AA.
AC   A0A3P8RLC3;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO9 {ECO:0000313|Ensembl:ENSAPEP00000000335.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000000335.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000000335.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000000335.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   AlphaFoldDB; A0A3P8RLC3; -.
DR   Ensembl; ENSAPET00000000343.1; ENSAPEP00000000335.1; ENSAPEG00000000245.1.
DR   GeneTree; ENSGT00940000158300; -.
DR   OMA; TIQIMNR; -.
DR   Proteomes; UP000265080; Chromosome 1.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF37; ANOCTAMIN-9; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        231..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        307..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        371..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        414..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        465..484
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        602..628
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        652..676
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        744..773
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          221..784
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   797 AA;  92110 MW;  D38DEB5004FA73DE CRC64;
     MNIFCTIDPS TSSVGKLQRG HQWVSYFGDV IFLHSLKSVS HRSEAVLHLS SSLLQARDCC
     CVFTDHADCA AGQRAVEQML KQPPTAQHSR TFDYVLVADK VDDEMDQKSQ RQKAFVEQLE
     KKNITVTKIV HDDKVFFGLR APREMFEDYQ YLLKVSDSCN WCGDVRGAVT QATRIRIIHF
     ILHQTFINTG GDLIIILSDH HCCNCIFGCF TVSTCVFSPC RYYFGEKVAL YYLWLGWYTK
     LLVPAAVLGV VVFLYGLAFF NTSPLIKEVC QSNITMCPRC DKRCPPWQLS DTCLYAKVSH
     LFDNEGTVAF AMFMAIWATL FLELWKRHRA RYVSKWKVYD WCEEEEELIM EIVSDPFCKP
     KQFRHSYLRS TVVLILVTLM LMLIIGLAHA LVVFRVVAAP LMSECQWEFL RDHANPVAVM
     FGAVLHYLTI QIMTRVNRWV SLKLCHIEKL NSFAATERSF TVKMFTFQFF TLFSSLFYVA
     FFLGRINGSP GNYVRIAGFR LEECHPSGCL TDLFIQMAVI MLLKQTLNNI FEFIVPWLKN
     CLSRNTAKKL ERKCGYCYRK ACRDEQGRVE PCDICKLRDW LRNYHLANTD AFSLFNEFLE
     MVIQFSFTTI FVAAFPLAPF LALINNIFEI RLDAIKMVRL ERRMIPRKTN DIGVWTKVLE
     AIGVLAVIAN GLVIGVTSDF IPRLVYRYRY GPCATGAAHT HCMQGYINDT LSTAFMKLTE
     PDRVITQCSY RDYRNEDYTL TSQFWLVLAV RFAFVILFEH VVVVCKFIAA WFVPNNPIQV
     KNDRLHDKLA RLKEEFR
//