ID A0A3P8RLH9_AMPPE Unreviewed; 795 AA.
AC A0A3P8RLH9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Leucine rich repeat containing 8 VRAC subunit C {ECO:0000313|Ensembl:ENSAPEP00000000395.1};
GN Name=LRRC8C {ECO:0000313|Ensembl:ENSAPEP00000000395.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000000395.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000000395.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000000395.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00024167};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324,
CC ChEBI:CHEBI:16382; Evidence={ECO:0000256|ARBA:ARBA00024145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328,
CC ChEBI:CHEBI:507393; Evidence={ECO:0000256|ARBA:ARBA00024158};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LRRC8 family.
CC {ECO:0000256|ARBA:ARBA00010471}.
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DR AlphaFoldDB; A0A3P8RLH9; -.
DR STRING; 161767.ENSAPEP00000000395; -.
DR Ensembl; ENSAPET00000000404.1; ENSAPEP00000000395.1; ENSAPEG00000000295.1.
DR GeneTree; ENSGT00940000159250; -.
DR OMA; YNSIMYI; -.
DR Proteomes; UP000265080; Chromosome 2.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021040; LRRC8_Pannexin-like.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF22; VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8C-LIKE; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF12534; Pannexin_like; 1.
DR SMART; SM00369; LRR_TYP; 7.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 3.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 30..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..329
FT /note="LRRC8 pannexin-like TM region"
FT /evidence="ECO:0000259|Pfam:PF12534"
FT REGION 169..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 795 AA; 92403 MW; 58694F02E6EF82B4 CRC64;
MIPVMEFRQF SEQQPAFRVL KPWWDVFTDY LSVIMLMIGV FGCTLQVMQD KIICLPQRIS
SISENSSEVE VKSLLHLQSN TSAVPREMTG LKTDLDLQQY SFINQMCYEK ALHWYAKYFP
YLVLIHTLVF MVCSNFWFKF PGSSSKIEHF ISMLGKCFDS PWTTRALSEV SGENPEEKDH
KKSSTSRSNI AVSPGEGSLE KTQSLRSIPE KIVVEKPSAS VLDKKEGEQA KALFEKVKKF
RLHVEEGDIL YLMYVRQTVF KVFKFLLIIA YNSSLVNKVR NRVRCEVEIQ DMTGYKDFEC
NHTMAHLFSK LSYCYLCLVA VYGLTSLYTS YWLFYRSLKE YSFEYVRQET GINDIPDVKN
DFAFMLHMID QYDPLYSKRF AVFLSEVSEN KLKQLNLNHE WTTEKLRQRL QTNANNRLEL
QLFMLPGLPD TVFELTELQS LKLEIINNVT IPASISQLED LQELSLYQCS LKLHTTATSF
LKENLKVLRV KFDDNRELPH WMYGLRNLEE LCLTGSLSPD ASKNIVLESL REMKCLKTLS
LKSNLTKIPQ SIVDVSSHLQ RLYLHNDGTK LVMLNNLKKM TNLIELELVR CDLERIPHAI
FSLTSLQELD LKENNLRSIE EIVSFQHLRK LTCLKLWYNG IMYIPEHIKK LGSLERLYFS
HNKIEILPSH LFLCNKLRYL DLSNNDIRFI PPEIGVLQSL QYFSVTCNKI ENLPDELFFC
KKLKTLKLGK NSLSILSPKI SYLALLTYLD LKGNHFELLP QELGCCRALK RSGLIVEETL
FETLPSDVRD QMKAE
//
