ID A0A3P8RMD2_AMPPE Unreviewed; 490 AA.
AC A0A3P8RMD2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Fascin {ECO:0000256|PIRNR:PIRNR005682};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000001222.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000001222.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000001222.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR005682}.
CC -!- SIMILARITY: Belongs to the fascin family.
CC {ECO:0000256|ARBA:ARBA00007415, ECO:0000256|PIRNR:PIRNR005682}.
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DR AlphaFoldDB; A0A3P8RMD2; -.
DR STRING; 161767.ENSAPEP00000001222; -.
DR Ensembl; ENSAPET00000001252.1; ENSAPEP00000001222.1; ENSAPEG00000000911.1.
DR GeneTree; ENSGT00950000183157; -.
DR OMA; MPANGNH; -.
DR Proteomes; UP000265080; Chromosome 19.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR CDD; cd00257; Fascin; 3.
DR Gene3D; 2.80.10.50; -; 4.
DR InterPro; IPR008999; Actin-crosslinking.
DR InterPro; IPR010431; Fascin.
DR InterPro; IPR022768; Fascin-domain.
DR InterPro; IPR024703; Fascin_metazoans.
DR PANTHER; PTHR10551; FASCIN; 1.
DR PANTHER; PTHR10551:SF24; FASCIN-2; 1.
DR Pfam; PF06268; Fascin; 4.
DR PIRSF; PIRSF005682; Fascin; 1.
DR SUPFAM; SSF50405; Actin-crosslinking proteins; 4.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR005682};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005682};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR005682};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 21..131
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 140..252
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 264..372
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 388..490
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
SQ SEQUENCE 490 AA; 54307 MW; 7C149F0E8673E698 CRC64;
MPANGNRPLK LQFGLINYEG RYLTAETFGF KVNASAPSLK KKQIWTLEQD SQDTQVVYLR
SHLGRYLASD KDGKVTCEAD GHNSDCRFLI VAQSDGRWAL QSEQYLRFFG GSRDYLSCFA
QIITDAELWA VHLALHPQAN LLSVARKRYA HLSMEDGEIA VDLNIPWGVA ALLTLVYLDG
KYCLKTCDSR FLSNDGKLVM QNGRATAYTL ELKCGKLAFK DCEGKYLSPM GPTGTLRSGR
CSKPGKDELF DLEESHPQVV LIAANGRYVS IRQGLSLAAN QEDETDMETF QMEIDKETKK
CTFRTSQGNY WALVAHGGVQ TTATEVSADT MFSVEWLGHK VALKANNGKY ICTKKNGQLL
AVSDSIGEDE QLTLKLINRP MLILRGLNGF ICHHKNSNTL DASRSVYDIF TLQFSNGAYN
IKGVDGQFWY VNSAGLVCSD GEAPEDFSLE LLEHGRLAIR GKNGKYLRGD QGGTLKGDGL
SLSSSALWEY
//
