ID   A0A3P8RR68_AMPPE        Unreviewed;      1090 AA.
AC   A0A3P8RR68;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Importin 4 {ECO:0000313|Ensembl:ENSAPEP00000003073.1};
GN   Name=IPO4 {ECO:0000313|Ensembl:ENSAPEP00000003073.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000003073.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000003073.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000003073.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; A0A3P8RR68; -.
DR   STRING; 161767.ENSAPEP00000003073; -.
DR   Ensembl; ENSAPET00000003143.1; ENSAPEP00000003073.1; ENSAPEG00000002112.1.
DR   GeneTree; ENSGT00550000075074; -.
DR   OMA; ANACGCV; -.
DR   Proteomes; UP000265080; Chromosome 22.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   InterPro; IPR034085; TOG.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF6; IMPORTIN-4; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 2.
DR   SMART; SM01349; TOG; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          23..89
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
FT   REPEAT          909..947
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REGION          302..324
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          630..656
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1090 AA;  119490 MW;  53872C379BFE2085 CRC64;
     MTEELEQILS QLTEPDNAVI QQATAKLKQA FKDPAIIPAL CAVMSGSQNP QIRQSAAVML
     RLRVKKHWKK ISPNDRESLK AVVLQAFMQE TEHSVQYSIS QLCAVMVKHE TPDRWPALLQ
     LLNESTKSSN PEDRQVGLLL LNKVMDSNPE PFKPHYCQLL QLFGTVLQDH ENPTALYYCI
     LTLTAITAYT GTGEMNQMRS IIPSLIVALK HLIKADQNQA SEAMEVFNEL MESEVSIIVP
     HVTDIVRFFL EVGSDTTLSD SLRVKALSCI AFLIKLKSKT VIKQKLLNPI LQAVFPVLIA
     APPPGEQDPE DEEDDTGDGT DNENTKHCAA QIIDTMALHM APEKLFQQLM PLTQACLVSE
     NPYQRKGAIM CLAVLAEGCA DHIRTKMLSS LLQTVCQSLS DSSQVVRSAG LFALGQFSEH
     LQPEVSKYCA ELMPLLLGYL SSLNEAKVGH VTKAFYALEN FMENLGADIE PYLPTLMETM
     LSALNNTDNL KIKELAVSAI GAIANAAKEL LVPYFSPVIE SLKGFLTTTT EEMRSLQTQS
     LDTLSVLART IGKDVFSPLA AECVQLGLNL TDTIDDPDLR RCTYGLYSAV SISSPDCLIP
     HLPAITTVML LALKSNEGIT AHLEEDKTFV LLDDDDDDDD DNEGENDGDD FLEDESETDV
     HDVAGFSVEN AYIDEKEDAC DALGEIAFST GAAFQPFLES SFQQIYEMRD FPHEDVRRAA
     FGAMGQFCRA QHKVWKENPT EANHQALLKL LEVVLPCFVE TVRTEPERLV VMGVLESMNG
     VIKSCEGEVF RNPSRLKEIS YVIRDVLKKK MVCQDGGGDE AEDEDQQAEY DAMLQEFAGE
     GIPLVASAVP ADSFAPFLND LLPLIMGKTK STGTVAERSF SLGTIGEILQ ALVTAPGGQG
     LAGRLSNRLL PVLVAGVRDS DPEVRNNSVF GLGCLAQAAG PIVLTDYPMM LSVFSNLLVK
     ESDARVIDNL CGALCRMILS NVEAVPLEQV VPALAARLPL KEDMEENKTV FSCLALLYTH
     SPALVVKVMK QIVAASSHVL DHKDVDKETQ NTAVLLMKQF AQNHCAEFQA AVRPLPAEQQ
     AKLSAVVTAS
//