ID   A0A3P8RS06_AMPPE        Unreviewed;       318 AA.
AC   A0A3P8RS06;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=NF-kappa-B inhibitor alpha {ECO:0000256|ARBA:ARBA00041123};
DE   AltName: Full=I-kappa-B-alpha {ECO:0000256|ARBA:ARBA00041987};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000002812.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000002812.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000002812.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NF-kappa-B inhibitor family.
CC       {ECO:0000256|ARBA:ARBA00038439}.
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DR   AlphaFoldDB; A0A3P8RS06; -.
DR   STRING; 161767.ENSAPEP00000002812; -.
DR   Ensembl; ENSAPET00000002876.1; ENSAPEP00000002812.1; ENSAPEG00000002043.1.
DR   GeneTree; ENSGT00940000163080; -.
DR   OMA; TYGLDNC; -.
DR   Proteomes; UP000265080; Chromosome 18.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR46680; NF-KAPPA-B INHIBITOR ALPHA; 1.
DR   PANTHER; PTHR46680:SF1; NF-KAPPA-B INHIBITOR ALPHA; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 5.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 3.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW   ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REPEAT          118..150
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          190..222
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          224..256
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          16..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          282..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        290..309
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   318 AA;  35791 MW;  FA701D062D439D06 CRC64;
     MDLHRTSILN QMDYSREAKE GKAAQSTEER LDSGLDSLKE EEYQAVAAEI LRLQLEHEPP
     QQHQAPAVTG ELYDWQSQIT EEGDTLLHLA IIHEAKNYIK TMVDLSKNTD FLNTQNDLRQ
     TPLHLAVITN QPDVCHSLLV SGCDPTLVDN SGDTPLHIAC RHGNLHCFSV ITQNCQPEHL
     HTAMVACNYN GQNCLHMASL HGFLSLVEKM VDLGADINSK EQHNGRSALH LAVDQQNLSL
     VRLLLQKGAD PNQLTSGGHT PYHLTYGLDN CDIRKELYSL TNPDLRELPE SESDESEEEE
     DEESDEEVRY DDIQWNGH
//