ID A0A3P8RTE2_AMPPE Unreviewed; 1115 AA.
AC A0A3P8RTE2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Integrin, alpha 11a {ECO:0000313|Ensembl:ENSAPEP00000003396.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000003396.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000003396.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000003396.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3P8RTE2; -.
DR Ensembl; ENSAPET00000003475.1; ENSAPEP00000003396.1; ENSAPEG00000002166.1.
DR GeneTree; ENSGT00940000155465; -.
DR Proteomes; UP000265080; Chromosome 1.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF21; INTEGRIN ALPHA-11; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 4.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1076..1097
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 32..94
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 177..358
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 368..419
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 518..576
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 580..640
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1115 AA; 125105 MW; 6259002CB86B62FF CRC64;
ARTEISSPLC PHTKVLLLML PFLFLGFFDC FNIDTKRHRI IKGPKQAQFG YTVQQHVAAG
GEKWLLVGAP YEMNGPYQTG DVYKCSLSKR TNGNSCSKLN LGRISLTNVS ERKDKMRLGM
TLASNPKDNS FVACGPLWSY ECGSSYYSTG ICSRVNASFK FSRTIAPAFQ RCETYMDIVI
VLDGSNSIYP WYEVQAFLIN ILQKFYIGPG QIQVGVVQYG EKVVHEFKLS DYKSVEEVVK
RARSIHQRGG EETNTALGIN MARSQAFKHG GRRGAKKVMI VITDGESHDS ADLQQAIEDS
ERDGITRYAI AVLGYYNRRG INPEAFLNEI KYIASDPDDK HFFNVTDESA LKDIVDALGE
RIFSLEGTSK NGTAFGLQMS QAGFSAHNVE DGILVGAVGA YDWNGAVLKE TRQGKVVPPK
SSYTEEFPEE LKNHGAYLGY TVTSVVSARN GRLLIAGAPR FNHTGKVIIF TLKNSGNLTI
LHSLKGQQVR QHPAYQPYAS YEIWYTYVTR QDNRFVLEGA LEIHNGGQNA RFGSSLAPVP
DLNGDGFNDL VVGAPLEDDH KGAIYVFFSQ HNRILRKYKQ RIAAADLAPG LQYFGRSIHG
TMDMNDDGLV DLAVGSLGAA VLLWSQSVIR IYATVRFEPS KINIFVKDCQ RAGKDVTCMS
AIVCFNITAR TAVPPTQEIG IKYNVSIVER RFNPRAVLDN PSKLQPQNLT LLPGEETCQH
IYFHVMETTD YARPIVFAVQ VGLQDPDSEP VLDESWPTVV RTELPFWNGC DEDDRCIPDL
ALQSMTDLMT PHEGWTEESQ RVLEANRRRM VVDIRLENKG ENAYHACLNI TYTPNLSFSS
LIVKDKLRNE KLCNVSAPFM RAKTQVSFRL EFEFSRTVFL DHLRVILEAS SDGEERSTAD
NSNDIYYSLK YEADLLFTRG SNPTRYEIKS ELSLEEPGII GPPFNFTFQI QNLGYFPVKD
LQLNIEIPEM TKNGNQLLQI SDFHIDQVSV NRSSPEDLTR FSRLVKQKPT TFIPELELYF
STLSCLLTLK FKILEVVTSA SVELASSSPM FLHEERPVRH IILEIRKEGD YRIPTWIIVG
STLGGLLLLA LLSLALWKVN NLSPFSCFIN KMPKA
//
