ID A0A3P8RU71_AMPPE Unreviewed; 1305 AA.
AC A0A3P8RU71;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Si:dkey-88l16.3 {ECO:0000313|Ensembl:ENSAPEP00000003417.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000003417.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000003417.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000003417.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSAPET00000003494.1; ENSAPEP00000003417.1; ENSAPEG00000002120.1.
DR GeneTree; ENSGT00940000162544; -.
DR Proteomes; UP000265080; Chromosome 16.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 12.
DR Gene3D; 4.10.1220.10; EGF-type module; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 10.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF12; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4 ISOFORM X1; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00057; Ldl_recept_a; 12.
DR Pfam; PF00058; Ldl_recept_b; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 12.
DR SMART; SM00135; LY; 7.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57424; LDL receptor-like module; 12.
DR SUPFAM; SSF63825; YWTD domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 6.
DR PROSITE; PS50068; LDLRA_2; 12.
DR PROSITE; PS51120; LDLRB; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1241..1264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 484..525
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 659..702
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 703..745
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1195..1234
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 13..28
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 63..78
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 102..117
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 141..156
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 187..202
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 226..241
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 265..280
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 285..297
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 292..310
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 304..319
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 325..337
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 344..359
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 386..401
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 406..418
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 413..431
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1224..1233
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1305 AA; 143960 MW; F33955318425953A CRC64;
MDRRSCISRN LICDGRPHCH DGSDELNCLG ATSLASRANV LKCRMGSRPC SDGTECVLYS
HVCDGENDCM DGSDEKGCRE TCSKGEFQCF HGKMCIPEAQ VCDGKPQCRD RSDELNCRER
SKSCDHRCSD GNRCIPKKFL CDGERDCPDG SDEVGCGESS ESVPLRCRRG FKLCKDGLDC
IMYSHLCDGE KDCQDGSDEE GCATLCKAGE FQCSHGKKCI PQERVCDGHY DCQDRSDEMD
CSKLVEGCHH LCDGKTRCIP DTFLCDGERD CADGSDEEKC GLVACEAHQY RCASGQCVSE
GLRCDGYADC SDRSDEADCQ RPPRCPSQLR CPHSHECLQK EWLCDGEDDC KDGSDEKNCN
TPPAKCREYQ WQCGDGSQCI PLSWRCDGKK DCYNGRDEDK CSQRKCPSHL YQCGSGECIG
PSLVCNKFIN CADGSDEGVG CAQRNCSSRS PPRCDHHCVS TPNGPRCYCA AGFRPQSNTL
SCVDIDECDS ASHTVCKHTC LNTRGSYSCH CHPGFYLEPD NKSCKTKDEP LLLASVQSEL
LLLGVHSGSL RLLSSVSRPV FSLDYHWAQQ RVYWLSPDYQ SIRWADIKTS NKGILIKGVK
SDFIAVDWVG KNLYWVDGLV GQILAVKLSN KTVKSQEYTV VLGEDLEQPS SLVLLPHRGL
MLWSEIGSTP QIERSGMDGS KRKVVVSRDL SWPVSLAYDL LDNRVYWADE KMRCIGSASL
DGDNVKILQL AETPSPFSVA VFNDRLFWSD TKRRTIRSAD KNTGKDQKVL LKRPGQPFGL
KLMHTLSQPA VSNPCDQLRC THLCLLAPAG KSRSGGLLLS KDNMTCSQPR ESSFVLLLSH
RMIYQIYLRS MRRDGVALKK MPNSRALTLP GTNEALGLDL SFKDLSLYVA YSGQGSVDVL
KLGSSRSRQG LAPLGQMLKL EDDSVTALAV DWVTSNLYWS SNGRPDIHVT SRYRGYTTSL
QYIGIDTISI ALHPPTGRLC YSTIVLAGGK SQTEVDCAWM DGRNKVVLWR KSHIPMSLVF
SNNGTMIYWA DIGEGVITSI GVDGSGYKQF KMGPGLLISF THTADILFWV TLDKDVTKLW
FSDGLQPKQL WFETKTSVLE VRAFSNNSQT GNNSCSNNNG GCIQLCLPYP GGRTCTCGWG
FYSINGTSCA PVPSCPAGEA SCFDSSKCIS SSKFCDGHVD CPDQSDEPMV QYFDNLPTCE
ETQCNSHGDC VPPPGGGTDL VCDCHLGYRG EFCEDTVNGA LSLPLTLSVI AVIIGLLILA
FILAKMRQRQ KKNRRYQSIT ECCHKLYQVL LSGSELGHCD HLFSP
//
