ID A0A3P8RWA6_AMPPE Unreviewed; 844 AA.
AC A0A3P8RWA6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Rho GTPase activating protein 27 {ECO:0000313|Ensembl:ENSAPEP00000003529.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000003529.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000003529.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000003529.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8RWA6; -.
DR STRING; 161767.ENSAPEP00000003529; -.
DR Ensembl; ENSAPET00000003613.1; ENSAPEP00000003529.1; ENSAPEG00000002491.1.
DR GeneTree; ENSGT00950000182860; -.
DR OMA; FEYTAND; -.
DR Proteomes; UP000265080; Chromosome 19.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04403; RhoGAP_ARHGAP27_15_12_9; 1.
DR CDD; cd12069; SH3_ARHGAP27; 1.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23176:SF104; RHO GTPASE-ACTIVATING PROTEIN 27; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00456; WW; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 3.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 11..74
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 237..268
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 301..335
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 396..429
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 653..841
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 220..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..289
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 844 AA; 95759 MW; DE4D6CA06F463ECF CRC64;
AALISGTMGL RSMELVLVQY EFEYKAKDGR LVSIKPNESY ILLSKTNEHW WHVRKDQHTR
PFYVPAQYVK ELAGVCQVPN KLNKTETENT PVDVSNVQPR KVCHGSAQDA SKETYRFSTF
GFCDDLPDVK PCETLKETRN SFSPTLDRMK LHNSAGGFSP PNSAVLDLSK LFKKLQIKTV
KLFIVFTTYM CVFCVSPQVE NANLRSAVYV NVAQLRQSIS ESPPSAPSSY SPSYLDPEGW
EVHVDQDSGQ EYYYHPATGQ TTWDSPFLDS PSDPEPPPAE EPFTPSPPQS PALSRSTASP
PARGSDWEQL VDETSGRPYF YNSMSGETSW EPPEPLTDPP EAYEELQATG PPTLPKEFTL
SHVTRTIIPR ANLDRSTPAG WNLTVEPGGT WVFTSENSPD QWIKSVDDRG QTYYYVRDGS
RSQWNLPEVK ILHSFTNSPQ LMVFRHQFVP THRRNTSDYS SDSSSTGNSP EMQHNVSLSL
PKNHFNCKPL LGLDLGEIRV LTFHKDPKSA APGNKTNQIV PEVTVDLRGA TIGWASKDKS
SKKNVLELKG RNGVEFLIQY DTESIISDWH KVLMDTIRQL DVHHHSDEED GDLYEKIGNT
ERDDKPSVTH SSSSAGETDP KKVRTKLMKF LMKRPTLQSV KEKGYIRENV FGCHLATLCQ
QERTTVPRFV EKCVRAVEKR GLDIDGLYRV SGNLAVIQKL RYKADHEELD LEDGQWEDVH
VITGALKLFF RELPEPLFPY SHFNKFISAI RIPDYNTKLS CIYELVKSLP PPNHDTMKLL
FGHLHRVIEY GEDNRMTVQN VAIVFGPTLL RPEMESSNIA MHMVFQNQIV EFILNEYERI
FRSS
//