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Database: UniProt
Entry: A0A3P8RWA6_AMPPE
LinkDB: A0A3P8RWA6_AMPPE
Original site: A0A3P8RWA6_AMPPE 
ID   A0A3P8RWA6_AMPPE        Unreviewed;       844 AA.
AC   A0A3P8RWA6;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Rho GTPase activating protein 27 {ECO:0000313|Ensembl:ENSAPEP00000003529.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000003529.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000003529.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000003529.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8RWA6; -.
DR   STRING; 161767.ENSAPEP00000003529; -.
DR   Ensembl; ENSAPET00000003613.1; ENSAPEP00000003529.1; ENSAPEG00000002491.1.
DR   GeneTree; ENSGT00950000182860; -.
DR   OMA; FEYTAND; -.
DR   Proteomes; UP000265080; Chromosome 19.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04403; RhoGAP_ARHGAP27_15_12_9; 1.
DR   CDD; cd12069; SH3_ARHGAP27; 1.
DR   CDD; cd00201; WW; 2.
DR   Gene3D; 2.20.70.10; -; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   PANTHER; PTHR23176:SF104; RHO GTPASE-ACTIVATING PROTEIN 27; 1.
DR   PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00397; WW; 2.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00456; WW; 3.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   SUPFAM; SSF51045; WW domain; 2.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   PROSITE; PS01159; WW_DOMAIN_1; 2.
DR   PROSITE; PS50020; WW_DOMAIN_2; 3.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          11..74
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          237..268
FT                   /note="WW"
FT                   /evidence="ECO:0000259|PROSITE:PS50020"
FT   DOMAIN          301..335
FT                   /note="WW"
FT                   /evidence="ECO:0000259|PROSITE:PS50020"
FT   DOMAIN          396..429
FT                   /note="WW"
FT                   /evidence="ECO:0000259|PROSITE:PS50020"
FT   DOMAIN          653..841
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          220..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          263..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          453..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          597..620
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        270..289
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        316..330
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   844 AA;  95759 MW;  DE4D6CA06F463ECF CRC64;
     AALISGTMGL RSMELVLVQY EFEYKAKDGR LVSIKPNESY ILLSKTNEHW WHVRKDQHTR
     PFYVPAQYVK ELAGVCQVPN KLNKTETENT PVDVSNVQPR KVCHGSAQDA SKETYRFSTF
     GFCDDLPDVK PCETLKETRN SFSPTLDRMK LHNSAGGFSP PNSAVLDLSK LFKKLQIKTV
     KLFIVFTTYM CVFCVSPQVE NANLRSAVYV NVAQLRQSIS ESPPSAPSSY SPSYLDPEGW
     EVHVDQDSGQ EYYYHPATGQ TTWDSPFLDS PSDPEPPPAE EPFTPSPPQS PALSRSTASP
     PARGSDWEQL VDETSGRPYF YNSMSGETSW EPPEPLTDPP EAYEELQATG PPTLPKEFTL
     SHVTRTIIPR ANLDRSTPAG WNLTVEPGGT WVFTSENSPD QWIKSVDDRG QTYYYVRDGS
     RSQWNLPEVK ILHSFTNSPQ LMVFRHQFVP THRRNTSDYS SDSSSTGNSP EMQHNVSLSL
     PKNHFNCKPL LGLDLGEIRV LTFHKDPKSA APGNKTNQIV PEVTVDLRGA TIGWASKDKS
     SKKNVLELKG RNGVEFLIQY DTESIISDWH KVLMDTIRQL DVHHHSDEED GDLYEKIGNT
     ERDDKPSVTH SSSSAGETDP KKVRTKLMKF LMKRPTLQSV KEKGYIRENV FGCHLATLCQ
     QERTTVPRFV EKCVRAVEKR GLDIDGLYRV SGNLAVIQKL RYKADHEELD LEDGQWEDVH
     VITGALKLFF RELPEPLFPY SHFNKFISAI RIPDYNTKLS CIYELVKSLP PPNHDTMKLL
     FGHLHRVIEY GEDNRMTVQN VAIVFGPTLL RPEMESSNIA MHMVFQNQIV EFILNEYERI
     FRSS
//
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