ID A0A3P8RWD8_AMPPE Unreviewed; 945 AA.
AC A0A3P8RWD8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000003559.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000003559.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000003559.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR AlphaFoldDB; A0A3P8RWD8; -.
DR STRING; 161767.ENSAPEP00000003559; -.
DR Ensembl; ENSAPET00000003641.1; ENSAPEP00000003559.1; ENSAPEG00000002572.1.
DR GeneTree; ENSGT01100000263500; -.
DR OMA; ACWTHEC; -.
DR Proteomes; UP000265080; Chromosome 21.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.10.20.370; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 338..517
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 945 AA; 104293 MW; 6B3A16C101FFBF27 CRC64;
MGGVSVPCLV DTGSMVSTVT ESFFRQHFEP WGQEKLQSCH WLQLRAANGL AIPYIGYLEL
EIGLCGKLMP HCGVLVVKDP PGGVSAQVPG VLGMNVIRKC YHELFGKHGL ALFDLPSVCE
APGTVVEALQ MCHQASVQAP QHNSGKVKVR GRKAWRIPGG VMQIVAATCS EQYSGNTVLF
EPLDSGLPAG LLASPALVRV TRGTAYIPIV NVGSTDVLLY PRTVVGSLDE VDVVSLPAGV
TEVPFGLATV ASQSVYTSVP EQIATMDLSS LPAGEQGQVR ALLTKYASVF AAYEGDLGCT
NLIAHDIPLL DDTPVPQRYR LISPSDYELA KEHIHQLLEA QVIRESSSPY ASPIVLVKKK
DGSLRMCVDY RQLNSKTRKD AFLLPRIEES LDALTGARWF STMDLASGYN QVPVAEADRP
KTAFCTPFGL FEWNRMPFGL CNAPSTFQQL MQRIFGDQQC QSLLLYLDDI VVFSSTIAQH
LDRLEVVLRQ LQQEGLKAKL TKCAFFQREV HYLGHVISDQ GVATDPSKVE VVANWQPPTT
ISELRSFLGF ASYYRRFVEG FAKLAAPLHR LVAELGGSKS GKRSMHALAE KWSYECQQSV
EALKAKLTTA PVLAYADFSL PFILEVDASH GGLGAVLSQE QGGKVRPIAY ASRGLRPTER
NMDNYSSMKL EFLALKWAMT EKFREYLLGH KCVVYTDNNP LSHLSSAKLG AMEQRWAAQL
ALFDFDIRYR SGRVNRNVDA LSRQHPSDAP DMKAMLPGTS LPEPLQQALW LEEANATQAV
IAALPHYAPS NLCQLQQADP VIQEVSVFWT QKRRPSHTER QQLSPRALAL LRQWDRLVEK
SGILYRQVYR PDGAAAILQL LLPAALKEEV LTEVHQRHGH QGVERTLELL RQRCYWPGMS
SDVAQGASLV RGARLPKTHS QLLAASWGIC WPLGQMKSSP WTSLC
//
