ID A0A3P8RWS4_AMPPE Unreviewed; 843 AA.
AC A0A3P8RWS4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Potassium voltage-gated channel, KQT-like subfamily, member 3 {ECO:0000313|Ensembl:ENSAPEP00000004556.1};
GN Name=KCNQ3 {ECO:0000313|Ensembl:ENSAPEP00000004556.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000004556.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000004556.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000004556.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3P8RWS4; -.
DR STRING; 161767.ENSAPEP00000004556; -.
DR Ensembl; ENSAPET00000004680.1; ENSAPEP00000004556.1; ENSAPEG00000003251.1.
DR GeneTree; ENSGT00940000159760; -.
DR OMA; QDRDDYM; -.
DR Proteomes; UP000265080; Chromosome 10.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:UniProt.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR020969; Ankyrin-G_BS.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR003948; K_chnl_volt-dep_KCNQ3.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR PANTHER; PTHR47735:SF11; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 3; 1.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR Pfam; PF11956; KCNQC3-Ank-G_bd; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01462; KCNQ3CHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 102..340
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 430..632
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..714
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 93143 MW; 2075E484D4E9A119 CRC64;
MGLRSRTVAS GSEEQKKPSS GAPPGDLLDQ GTGGADKDGA LLLVASGRDD YKRGSQGIGI
GLLAKTPLSY TRPAKRNNIR KRRIQNLIYD ALERPRGWAL LYHAFVFLIV LGCLILAILT
TFKEHEKTSA HWLVILETFA IFIFGAEFAL RIWAAGCCCR YKGWRGRLKF ARKPLCMLDI
FVLIASVPVV AVRNQGNVLA TSLRSLRFLQ ILRMLRMDRR GGTWKLLGSA IYAHSKELIT
AWYIGFLSLI LASFLVYLVE KDDVSMNVSD HENPTAQPKP QDFDTYADAL WWGLITLTTI
GYGDKTPKTW AGRLLAGTFA LIGVSFFALP AGILGSGLAL KVQEQHRQKH FEKRRHPAAG
LIQSAWRYYS TNPIREDLIA TWRFYETVIS LPCFRKETLE VMASQKLSLL ERVRLPTARP
SVGSGKKLSG NGESIEDSPS KEPKPAGFSN RERFRTAFRM KAYTLRQSSE DAGALADPAL
EERGFPPDIL LEEMIPTLKL VIRAVRIMQF LLNKKRFKET LRPYDVKDVI EQYSAGHLDM
LCRIKYLQTR IDMILAPGPP LTPKHKKTQK TPFAYPSNQS PRHESYLAKA ASMPDAEDQS
MMGRFVRVER QVEDMEKKLD FLVDMHIQHT EHLQVDSAGG AQMTLETCDP TGNGGIRRVF
FNYAEAFPHM SFQVPVSKVN PFYGRGQGGR EGPGLVGGGP VPPDHHPPPS HLHQAPGAIP
TYTERPTVLP ISSLQDLSVG LGRTTGGRGA DSPLSMLSVN HEELERSPSG FSISGEREGE
EGVGLSMGAG VATGDASWTR PRPSYLAEGE TDTDTDPFTP SGGPLPLSST GEGFGDAVWN
TPP
//
