ID A0A3P8RX67_AMPPE Unreviewed; 549 AA.
AC A0A3P8RX67;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=BOS complex subunit NCLN {ECO:0000256|ARBA:ARBA00034873};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000004285.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000004285.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000004285.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR AlphaFoldDB; A0A3P8RX67; -.
DR STRING; 161767.ENSAPEP00000004285; -.
DR Ensembl; ENSAPET00000004402.1; ENSAPEP00000004285.1; ENSAPEG00000003039.1.
DR GeneTree; ENSGT00500000044945; -.
DR OMA; GGCITAY; -.
DR Proteomes; UP000265080; Chromosome 6.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR CDD; cd03882; M28_nicalin_like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR016574; Nicalin.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR31826; NICALIN; 1.
DR PANTHER; PTHR31826:SF3; NICALIN-1-LIKE; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR PIRSF; PIRSF011018; Nicalin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..549
FT /note="BOS complex subunit NCLN"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018085928"
FT TRANSMEM 509..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 194..325
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 549 AA; 61936 MW; 5C13CB32531835C9 CRC64;
MLLSVAVAVL LLCVQCLHGS ALPAVSSYEF TAYRMQQYNM AQQKHGCRGA IVVAEARSAD
EPSLTRRCVI MKVSDFTTER YFEAQRQNAA AVLILLPKNI SGICHDTLQS FMVSESEALQ
KETLMPVYVA PEDEQLLYMY EEVKQAAATR TSSIFVRVLR SMVTATAFQI FVSNNVAIKA
VTDNSIVTLE GVLPGAGEDI PTIVITAHYD SYGLAPWLSY GADSNGSGVT ILLELARLFQ
KLYSSSSTRP QYHLMFSLTG GGKYNFQGTK RWIEENLDHA ESSLLHDNVA FVLCLDTLAN
GDELYMHVSR PPKPDTPMHS FIQHLEEVVS SRFPWVKVGL VHKKINLVES TVAWEHERYS
LRRILGFTLS HLEDPKSELR GSILDTMSQV DFRKLKRNGI IIAEALARYM YNLSDKGSPK
DVQVFKGQLD FQDSRISSLL SFLTSIPRAT QLLDKEPSHI LLVNSLEHEF KRYLQQVYRH
TFRQDKRDPD ITFFDQMNQP VVMYRVKPAA FDLFLGGCIA AYLGIVYYGI QNFGFLYTKL
KAAVKSKQQ
//
