ID A0A3P8RXM5_AMPPE Unreviewed; 1138 AA.
AC A0A3P8RXM5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Neurofascin homolog (chicken) a {ECO:0000313|Ensembl:ENSAPEP00000004465.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000004465.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000004465.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000004465.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR AlphaFoldDB; A0A3P8RXM5; -.
DR STRING; 161767.ENSAPEP00000004465; -.
DR Ensembl; ENSAPET00000004584.1; ENSAPEP00000004465.1; ENSAPEG00000003153.1.
DR GeneTree; ENSGT00940000157024; -.
DR OMA; NHSSYPG; -.
DR Proteomes; UP000265080; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF12; NEUROFASCIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1009..1030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..111
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 125..212
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 226..314
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 319..406
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 417..499
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 503..590
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 597..692
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 697..791
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 796..900
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 904..997
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 676..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1041..1138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1041..1068
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1083
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1138 AA; 127798 MW; 37E1037E83BFE4C7 CRC64;
QQIIWSHHLL IGTAINQADS QPPTIIKQSV KDYIVDPRDN IIIECEAKGN PVLTFSWRRN
GKFFNIGKDP RVTMRKRSGT LEIGFRSGGR PEDYEGEYQC FANNDLGVAL SNKILLRVSK
APLWPKEVLE PVSVTEGSPL VLPCNPPPGL PPPFTFWMDS SMSPIPQDKR VSMGLNGDLY
FSNVLAQDAH TDYSCNARFL FTHTIQQKNP FTLKVQTSRK VAESTPIFLS PPGTESSKMV
LRDEQLLLEC IAAGLPTPTI KWFKKGGDLP GRKVKFENYN KTLKIINVSE EDAGEYVCMA
NNHLGSIRHS IFVQIKAAPY WLDKPSDLVL APDENGRLVC RANGNPKPNI QWLINGHPIE
SYPSSPNRQE LGDTIIFRSV QIGSSAVYQC NASNQHGYLL ANAFVSVLDM PPRMLGPKNQ
LIKVIENNRT FLDCPFFGSP LPDLRWFKNG QGSGLDGGQY RVYINGTLEI KRARAEDEGT
YTCVANSILG TAENQVRLEV KEPTRIVRLP EHQSAIRGST ARFDCKVKSD PSLTVTVAWM
KDDKPLHLGW RLRKDEESLT IPNVNEGDEG TYTCAVKSEI DQDSASARLT VLDRPDPPMD
LDLSDPAARS VRLTWIPGND HRSPITEFLV QFEEDRWEPN RWQNLSTYPG DLNSVILQLA
PFVNYQFRVI AINSVGQSQP SRPSPRYKTS GAAPDAIPRG LRGWGSKKDN MEITWEVRCA
KMSRNGPNLH YSIWWRRKDS GEEWSNVTTV GSKHVVHNTE TYVPYEIKLQ ARNEFGSGPE
SNVIIGYSGE DKPTDAPTDL RVSKVDSTKA NVHWKPVDPN TVQGEFKEYR LYYWRESSQV
PGLIVSKEKK TKGFYSTTAE PSGILSDLVP YSKYKMFMVV ANSHFEGPPS NTVEFNTKEG
VPDAPRSFRI YRRSLDTIYL EWEKPLEPNG ILIGYQLRYQ TGKLGRSHLE TFLPNVTDFT
LRLSDRSTRY KFFLSALTQV GTGEVYAEES PHFTNEAYID HVDIATQGWF IGLMCAIALI
ILILLIVCFI KRSRGGKYPV RDKKDLPLDP VDQKDQDGSF DYHSDEDNKP LQGSQTSLDG
NVKESDDSLV DYGEGGDGQF NEDGSFIGQY TVKKDKDETE GNESSEATSP VNAIYSLA
//
