ID A0A3P8RYB2_AMPPE Unreviewed; 883 AA.
AC A0A3P8RYB2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000004715.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000004715.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000004715.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3P8RYB2; -.
DR STRING; 161767.ENSAPEP00000004715; -.
DR Ensembl; ENSAPET00000004841.1; ENSAPEP00000004715.1; ENSAPEG00000003144.1.
DR GeneTree; ENSGT01050000244874; -.
DR Proteomes; UP000265080; Chromosome 9.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF519; EXTRACELLULAR CALCIUM-SENSING RECEPTOR-LIKE; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..883
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017951115"
FT TRANSMEM 579..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 616..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 649..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 738..761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 773..793
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..828
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 849..867
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 579..843
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 883 AA; 98153 MW; CA36DFDE2AA81A48 CRC64;
MPRATLVFLC VLHLNTVSGC ELFGRFDMPS LFHHGDIMIG GIFPVFNKEQ QQQQFCNFIN
FFRFDLRAFR WTQVMIFAIE EINKDPALLP NISLGYRILN SCASPTNALR AALTLASRPE
ETEFNSSCPP TISAVIAASG SSQSLAVAGT LGPFQVPIVS YFSTCACLSD RAKYPTFFRT
IPSDYFQAKA LAALVKHFGW QWIGAIQSDN DYGRNGILSF TEEVKKLGVC IAFVGTILRT
YSMDKILDVV EMIRRSTVKV ILAFVPEGDF YPLMKEVVKQ NITGIQWIAS EAWITAARPS
TPEIYQAFGG ALGFVVQKMA MPKLKPFLTN INPYTDPSAA FVKDFWEIMV GCRPVLPEEH
RMDKICTGNE TLLNSQHAFF DVTQLRVTYN VYKAVYAIAH ALHQLIFCKP AGQKPVRPCL
NVSEIQPKEV TDHLQRVNFR NEFGDDVFFD ENGDPPASYD IINWQLRNGQ VQHVTLGHFA
SAANGDFRLN IQEEKIVWRT GKRVPTSVCS NVCPVGTRKA QIKGKPTCCF DCIPCADGTI
ANSTGAADCT PCPQEYWSNE RKDECIPKTT EFLRYHEPMG IALTVVSLLG ASLSLVTMMV
FIHYRETPVI KASNSELSCF LLFSLFLCFL CPLTFMGRPT VWTCMLRHTA FGVTFALCIS
CVLGKTIVVV TAFKATIPGN KVAGKFGPAQ QRIIVCSCTM IQILICVLWL KFKPPFPDMV
FRYSNKKIVL ECNTGSEAAF YAVLGYIGIL AIVCLVLAFL ARKLPDNFNE AKFITFSMLI
FCAVWITFIP AYISSPGKFT VAVEIFAILS SAFGLLSSIF APKCYIILVK PEKNTKKHVM
GINDSNPTII IIIIIIIIII MSSSSSSSSS SSSIITNFRS ILT
//
